ArticleLeukemia & lymphoma2020
The geriatric syndrome of sarcopenia impacts allogeneic hematopoietic cell transplantation outcomes in older lymphoma patients.
Article in Leukemia & lymphoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sarcopenia and clinical outcomes in lymphoma and multiple myeloma patients receiving hematopoietic cell transplantation: a systematic review and meta-analysis.International journal of hematology · 2025Pooled it
- Low skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Prevalence and effect on survival of pre-treatment sarcopenia in patients with hematological malignancies: a meta-analysis.Frontiers in oncology · 2023Pooled it
- Risk Stratification of Non-Relapse Mortality After Allogeneic Hematopoietic Stem Cell Transplantation Based on Pre-Transplant Sarcopenia and HCT-CI.Blood cell therapy · 2026Article
- Review
- Value of ultrasound assessment of sarcopenia in patients with diffuse large B-cell lymphoma: a prospective study.Radiology and oncology · 2025Article
- An integrative review of cancer-related cachexia and sarcopenia: A different focus in malignant hematology.Health sciences review (Oxford, England) · 2024Article
- Changes in skeletal muscle function during chemotherapy and related factors in patients with acute leukemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Risk of Sarcopenia Identified by Sarc-Calf, Nutritional Status and Hand Grip Strength in Patients with Hematological Cancer.International journal of hematology-oncology and stem cell research · 2024Article
- Semiquantitative 2-[Frontiers in medicine · 2024Review
- Muscle and fat composition in patients with newly diagnosed multiple myeloma.Blood cancer journal · 2023Article
- The association of body composition and outcomes following autologous hematopoietic stem cell transplantation in patients with non-Hodgkin lymphoma.Bone marrow transplantation · 2023Article
- Longitudinal Body Composition Changes Detected by [Cancers · 2022Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
Older patients with advanced hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation (allo-HCT) yet their survival outcomes remain suboptimal. We and others have previously shown that pre-HCT multi-morbidity and functional limitation and post-HCT geriatric syndromes significantly impact outcomes. Sarcopenia, an accelerated loss of muscle mass and function, has been increasingly recognized in older cancer patients. We identified 146 lymphoma patients 50 years or older who were allografted from 2008 to 2018 at our institution and found that before allo-HCT, 80 (55%) patients were sarcopenic. Pre-HCT sarcopenia was significantly associated with overall survival, progression-free survival, and nonrelapse mortality independent of multi-morbidity and functional limitation. In 6-month landmark analysis, post-HCT sarcopenia remained significantly associated with survival. Our findings illustrate the high prevalence and profound impact of sarcopenia on survival. While requiring prospective confirmation, preemptive, longitudinal, and multidisciplinary interventions for sarcopenia are warranted to improve HCT outcomes for older patients.
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