ArticleRadiology2020
Kinetic Heterogeneity of Breast Cancer Determined Using Computer-aided Diagnosis of Preoperative MRI Scans: Relationship to Distant Metastasis-Free Survival.
Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Impact of Preoperative Magnetic Resonance Imaging on Surgical Outcomes in Women with Invasive Breast Cancer: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- DCE-MRI kinetic heterogeneity facilitates the discrimination of benignity and malignancy of breast in combination with the DWI and morphological features.European journal of radiology open · 2026Article
- Enhanced recurrence risk stratification for stages Ⅱ-Ⅲ breast cancer using MRI-based structure habitat imaging.European radiology · 2026Article
- Comparative analysis of the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging kinetic heterogeneity and apparent diffusion coefficient for grading invasive breast cancer.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Predicting early-stage breast cancer disease-free survival and adjuvant therapy benefit from multimodal information using deep learning.NPJ breast cancer · 2026Article
- Article
- A study on the prognostic assessment of triple-negative breast cancer using habitat analysis of preoperative DCE-MRI subtraction maps.Frontiers in oncology · 2026Article
- Kinetic heterogeneity is associated with axillary lymph node metastasis in cN0 breast cancer based on dynamic contrast-enhanced magnetic resonance imaging radiomics nomogram.Breast cancer (Tokyo, Japan) · 2026Article
- Angiovolume and Peak Enhancement on Preoperative CAD-Derived MRI as Prognostic Factors in Primary Operable Triple-Negative Breast Cancer.Tomography (Ann Arbor, Mich.) · 2025Article
- Development and validation of an MRI spatiotemporal interaction model for early noninvasive prediction of neoadjuvant chemotherapy response in breast cancer: a multicentre study.EClinicalMedicine · 2025Article
- Quantifying tumor morphological complexity based on pretreatment MRI fractal analysis for predicting pathologic complete response and survival in breast cancer: a retrospective, multicenter study.Breast cancer research : BCR · 2025Article
- Superior performance in classification of breast cancer molecular subtype and histological factors by radiomics based on ultrafast MRI over standard MRI: evidence from a prospective study.La Radiologia medica · 2025Observational
- DCE-MRI-based machine learning model for predicting axillary lymph node metastasis in breast cancer.Gland surgery · 2025Article
- Evaluating dynamic contrast-enhanced MRI for differentiating HER2-zero, HER2-low, and HER2-positive breast cancers in patients undergoing neoadjuvant chemotherapy.European journal of medical research · 2025Article
- Lesion Conspicuity in Contrast-Enhanced Mammography: A Retrospective Analysis of Tumor Characteristics.Cancers · 2025Article
- Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes.Frontiers in molecular biosciences · 2025Article
- Diagnostic value of qualitative and quantitative enhancement parameters on contrast-enhanced mammographyDiagnostic and interventional radiology (Ankara, Turkey) · 2024Article
- The value of the malignant subregion-based texture analysis in predicting the Ki-67 status in breast cancer.Frontiers in oncology · 2024Article
- Tumor Heterogeneity of Breast Cancer Assessed with Computed Tomography Texture Analysis: Association with Disease-Free Survival and Clinicopathological Prognostic Factor.Diagnostics (Basel, Switzerland) · 2023Article
- Machine Learning Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy for ER+HER2- Breast Cancer: Integrating Tumoral and Peritumoral MRI Radiomic Features.Diagnostics (Basel, Switzerland) · 2023Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background Higher peak enhancement and washout component values measured on preoperative breast MRI scans with computer-aided diagnosis (CAD) are presumed to be associated with worse recurrence-free survival. Purpose To investigate whether CAD-extracted kinetic features of breast cancer and the heterogeneity of these features at preoperative MRI are associated with distant metastasis-free survival in women with invasive breast cancer. Materials and Methods Consecutive women with newly diagnosed invasive breast cancer who underwent preoperative MRI were retrospectively evaluated between 2011 and 2012. A commercially available CAD system was used to extract the peak enhancement and delayed enhancement profiles of each breast cancer case from preoperative MRI data. The kinetic heterogeneity of these features (a measure of heterogeneity in the proportions of tumor pixels with delayed washout, plateau, and persistent components within a tumor) was calculated to evaluate intratumoral heterogeneity. Cox proportional hazards models were used to investigate the associations between CAD-extracted kinetic features and distant metastasis-free survival after adjusting for clinical-pathologic factors. Results A total of 276 consecutive women (mean age, 53 years) were evaluated. In 28 of 276 (10.1%) women, distant metastasis developed at a median follow-up of 79 months. A higher degree of kinetic heterogeneity was observed in women with distant metastases than in those without distant metastases (mean, 0.70 ± 0.2 vs 0.43 ± 0.3;
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