Evidence map›Paper›PMID 32227851›Full record

ArticleBiochemistry2020

Skp1 Dimerization Conceals Its F-Box Protein Binding Site.

Hyun W Kim, Alexander Eletsky, Karen J Gonzalez, Hanke van der Wel, Eva-Maria Strauch, James H Prestegard, Christopher M West

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Structure-guided optimization of SLY1 expression and purification in Escherichia coli.Protein science : a publication of the Protein Society · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Cargo competition for a dimerization interface restricts and stabilizes a bacterial protease adaptor.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyun W Kim
Alexander Eletsky
Karen J Gonzalez
Hanke van der Wel
Eva-Maria Strauch
James H Prestegard
Christopher M WestORCID 0000-0001-9077-965X
University of Georgia · US

Funding

TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI BOONS, GEERT-JAN · 2012 to 2019
$14.5M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NMR of Cell Surface OligosaccharidesR01GM033225 · NIGMS · YALE UNIVERSITY · PI PRESTEGARD, JAMES H. · 1985 to 2021
$4.6M
Transfer of 5R01GM037539 - 22 CYTOSOLIC PROLINE HYDROXYLATION AND GLYCOSYLATIONR01GM037539 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI WEST, CHRISTOPHER M. · 1986 to 2016
$4.4M
Design of Antivirals and Immunogens Targeting ParamyxovirusesR01AI140245 · NIAID · WASHINGTON UNIVERSITY · PI STRAUCH, EVA-MARIA · 2018 to 2023
$1.9M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
Sparse NMR Labeling Approach to Glycoprotein Structure and FunctionR01GM134335 · NIGMS · UNIVERSITY OF GEORGIA · PI PRESTEGARD, JAMES H. · 2019 to 2022
$1.2M
NIAID NIH HHS R01 AI140245NIGMS NIH HHS P41 GM103311NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R01 GM033225NIGMS NIH HHS R01 GM037539NIGMS NIH HHS R01 GM134335NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

Skp1 is an adapter that links F-box proteins to cullin-1 in the Skp1/cullin-1/F-box (SCF) protein family of E3 ubiquitin ligases that targets specific proteins for polyubiquitination and subsequent protein degradation. Skp1 from the amoebozoan

Indexed as

Binding SitesDimerizationF-Box ProteinsHumansModels, MolecularS-Phase Kinase-Associated ProteinsF-Box ProteinsSKP1 protein, humanS-Phase Kinase-Associated Proteins

Identifiers

PMID32227851
PMCPMC7521599
OpenAlexW3013597974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.