Evidence map›Paper›PMID 32227839›Full record

ArticleThe journal of physical chemistry. B2020

Supramolecular Approach to Electron Paramagnetic Resonance Distance Measurement of Spin-Labeled Proteins.

Zhimin Yang, Richard A Stein, Thacien Ngendahimana, Maren Pink, Suchada Rajca, Gunnar Jeschke, Sandra S Eaton, Gareth R Eaton, Hassane S Mchaourab, Andrzej Rajca

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins.Journal of the American Chemical Society · 2023
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Zhimin YangDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.
Richard A SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, United States.
Thacien NgendahimanaDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
Maren PinkIUMSC, Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Suchada RajcaDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.ORCID 0000-0003-0904-8329
Gunnar JeschkeDepartment of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, CH-8093 Zürich, Switzerland.ORCID 0000-0001-6853-8585
Sandra S EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.ORCID 0000-0001-7429-8469
Gareth R EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
Hassane S MchaourabDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, United States.
Andrzej RajcaDepartment of Chemistry, University of Nebraska, Lincoln, Nebraska 68588-0304, United States.ORCID 0000-0002-8856-1536
University of Denver · USUniversity of Nebraska–Lincoln · USVanderbilt University · USETH Zurich · CHIndiana University Bloomington · US

Funding

New Nitroxide Spin Labels for Distance Measurements in Biological SystemsR01GM124310 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI RAJCA, ANDRZEJ · 2017 to 2020
$1.7M
NIGMS NIH HHS R01 GM124310
6 · The paper itself

Abstract

We demonstrate a host-guest molecular recognition approach to advance double electron-electron resonance (DEER) distance measurements of spin-labeled proteins. We synthesized an iodoacetamide derivative of 2,6-diazaadamantane nitroxide (DZD) spin label that could be doubly incorporated into T4 Lysozyme (T4L) by site-directed spin labeling with efficiency up to 50% per cysteine. The rigidity of the fused ring structure and absence of mobile methyl groups increase the spin echo dephasing time (

Indexed as

MuramidaseProteinsElectron Spin Resonance SpectroscopySpin LabelsTemperatureMuramidaseProteinsSpin Labels

Identifiers

PMID32227839
PMCPMC8256814
OpenAlexW3013270396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.