Evidence map›Paper›PMID 32227760›Full record

ArticleThe New England journal of medicine2020

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19.

Muthiah Vaduganathan, Orly Vardeny, Thomas Michel, John J V McMurray, Marc A Pfeffer, Scott D Solomon

6 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New England journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 1,224 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,224citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04345887 completednot on this map

The Effect of Spironolactone on Oxygenation in Covid-19 ARDS Patients

Typeobservational_patient_registrySponsorIstanbul University - CerrahpasaRan2020 to 2020Enrolled60ConditionsRespiratory Distress Syndrome, AdultArmsSpironolactone 100mg, Placebo oral tablet
NCT04420260 nacompletednot on this mapstarted 2021, after this paper: background citation

Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia

TypeinterventionalSponsorUnidad de Investigación Genética MolecularRan2021 to 2021Enrolled152ConditionsCOVIDArmsGroup A: oropharygeal spray and immunostimulant emulsion, Group D:Placebo oropharyngeal spray + Placebo taken PO
NCT04466670 phase2unknown statusnot on this map

Dynamics of Hemostatic Parameters in COVID-19 and Comparison of Intervention Strategies Through Adaptive Clinical Trial

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2020 to 2022Enrolled379ConditionsCOVID-19Armsacetylsalicylic acid, Unfractionated heparin nebulized
NCT04508985 nacompletednot on this map

Management of Renin-Angiotensin-Aldosterone System Blockade in Patients Admitted in Hospital With Confirmed Coronavirus Disease (COVID-19) Infection: The McGill RAAS-COVID-19 Randomized Controlled Trial

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2020 to 2021Enrolled46ConditionsCOVID-19, Cardiovascular DiseasesArmsTemporarily holding the RAAS inhibitor [intervention], RAAS inhibitor [continued standard of care]
NCT04510662 phase2completednot on this map

Effectiveness and Safety of Telmisartan in Acute Respiratory Failure Due to COVID-19

TypeinterventionalSponsorAbraham Edgar Gracia-RamosRan2020 to 2021Enrolled66ConditionsCOVID-19, Respiratory Insufficiency, Telmisartan, Respiratory Distress Syndrome, AdultArmsTelmisartan
NCT05304702 completednot on this mapstarted 2021, after this paper: background citation

Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL): a Case-Control Study

TypeobservationalSponsorClinica ColonRan2021 to 2022Enrolled120ConditionsCOVID-19
3 · Its place in the literature

Who cites it

1,224 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  9. Endometriosis and COVID-19: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022
    Pooled it
  10. New-Onset Diabetes Mellitus, Hypertension, Dyslipidaemia as Sequelae of COVID-19 Infection-Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  11. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
    Pooled it
  12. Pooled it
  13. Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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1,164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Muthiah VaduganathanFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).
Orly VardenyFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).
Thomas MichelFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).
John J V McMurrayFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).ORCID 0000-0002-6317-3975
Marc A PfefferFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).
Scott D SolomonFrom the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBetacoronavirusCoronavirus InfectionsCOVID-19Down-RegulationHumansHypertensionPandemicsPeptidyl-Dipeptidase APneumonia, ViralRenal Insufficiency, ChronicRenin-Angiotensin SystemSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsPeptidyl-Dipeptidase A

Identifiers

PMID32227760
PMCPMC7121452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.