ArticleChembiochem : a European journal of chemical biology2020
Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells.
Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 22 citations in OpenAlex.
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- Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates.Organic letters · 2021Article
- Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation.Chemical science · 2021Article
- Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells.Chembiochem : a European journal of chemical biology · 2020Article
- Caged luciferins enable rapid multicomponent bioluminescence imaging.Photochemistry and photobiologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR
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