Evidence map›Paper›PMID 32227590›Full record

ArticleMicrobial biotechnology2020

Exosome-derived uterine miR-218 isolated from cows with endometritis regulates the release of cytokines and chemokines.

Xiangguo Wang, Xinxin Yao, Tongtong Xie, Zhenyu Chang, Yong Guo, Hemin Ni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  13. Expression Analysis ofInternational journal of molecular sciences · 2022
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  15. Tracking tools of extracellular vesicles for biomedical research.Frontiers in bioengineering and biotechnology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiangguo WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Xinxin YaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Tongtong XieAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Zhenyu ChangAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Yong GuoAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.
Hemin NiAnimal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, China.ORCID 0000-0001-8222-251X
Beijing University of Agriculture · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an inflammation of the endometrium, endometritis can affect fertility and lead to serious economic losses in the dairy industry. Widely found in various tissues and body fluids, exosomes and exosome micro (mi)RNAs have been shown to play an important regulatory role in the immune responses. As one of differentially expressed exosome miRNAs, miR-218 is involved in the pathogenesis of bovine endometritis. The mechanisms of miR-218 in regulating the release of cytokines and chemokines in endometritis, however, are poorly understood. Exosomes were isolated from bovine uterine cavity fluid and verified by transmission electron microscopy. An in vitro lipopolysaccharide-treated cell model for bovine endometritis was then established to evaluate the correlation between exosome-derived miR-218 and the immune responses. We demonstrated that exosomes could be used to deliver miR-218 from endometrial epithelial cells (EECs) into the uterine microenvironment and adjacent recipient cells to modulate local immune responses. miR-218 packaged in the exosomes secreted from EECs acts as an inhibitor by blocking immune factors such as interleukin (IL)-6, IL-1β, tumour necrosis factor-α, the chemokines macrophage inflammatory genes (MIP)-1α and MIP-1β to maintain the immune balance in the uterus. However, uterine inflammation altered the immunoregulatory mechanism of exosome miR-218. MiR-218 is a potential biomarker for the detection of endometritis. Our findings also revealed a new mechanism for the development of endometritis in cows.

Indexed as

Cattle DiseasesEndometritisExosomesMicroRNAsAnimalsCattleChemokinesCytokinesFemaleChemokinesCytokinesMicroRNAs

Identifiers

PMID32227590
PMCPMC7264886
OpenAlexW3014083212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.