Evidence map›Paper›PMID 32227589›Full record

ArticleJournal of cellular and molecular medicine2020

FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation.

Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Protective effects of exerkine on cardiovascular system.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Mechanism of fibroblast growth factor 21 in cardiac remodeling.Frontiers in cardiovascular medicine · 2023
    Review
  17. Review
  18. Adipokines in atherosclerosis: unraveling complex roles.Frontiers in cardiovascular medicine · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Lin XiaolongDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.ORCID 0000-0002-9272-2945
Guo DongminKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang City, China.
Mihua LiuDepartment of infectious Disease, Centre for Lipid Research & Key Laboratory of Molecular Biology for infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing City, China.
Wang ZuoKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang City, China.
Hu HuijunDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Tan QiufenDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Hu XueMeiDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Lin WenshengDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Pan YupingDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Lin JunDepartment of Pathology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou City, China.
Zeng ZhaolinKey Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang City, China.ORCID 0000-0002-9479-3982
Third Affiliated Hospital of Guangzhou Medical University · CNUniversity of South China · CNChongqing Emergency Medical Center · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast growth factor 21 (FGF21) acts as an anti-atherosclerotic agent. However, the specific mechanisms governing this regulatory activity are unclear. Autophagy is a highly conserved cell stress response which regulates atherosclerosis (AS) by reducing lipid droplet degradation in foam cells. We sought to assess whether FGF21 could inhibit AS by regulating cholesterol metabolism in foam cells via autophagy and to elucidate the underlying molecular mechanisms. In this study, ApoE

Indexed as

AutophagyAdenineAnimalsApolipoproteins EAtherosclerosisATP Binding Cassette Transporter 1Autophagy-Related Protein 5Beclin-1CholesterolFibroblast Growth FactorsFoam CellsLipidsMaleMiceMice, TransgenicReceptors for Activated C Kinase3-methyladenineAbca1 protein, mouseAdenineApolipoproteins EAtg5 protein, mouseATP Binding Cassette Transporter 1Autophagy-Related Protein 5Beclin-1Becn1 protein, mouseCholesterolfibroblast growth factor 21Fibroblast Growth FactorsLipidsRACK1 protein, mouseReceptors for Activated C Kinaseatherosclerosisautophagyfibroblast growth factor 21RACK1

Identifiers

PMID32227589
PMCPMC7205825
OpenAlexW3013888613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.