Evidence map›Paper›PMID 32227524›Full record

ReviewInternational journal of experimental pathology2020

Experimental models and methods for cutaneous wound healing assessment.

Daniela S Masson-Meyers, Thiago A M Andrade, Guilherme F Caetano, Francielle R Guimaraes, Marcel N Leite, Saulo N Leite, Marco Andrey C Frade

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655388 (Impact of Dressing Type and Dressing Change Frequency on Surgical Wound Healing Following Primary Total Hip Arthroplasty), which is not on this map. Cited by 213 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655388 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Dressing Type and Dressing Change Frequency on Surgical Wound Healing Following Primary Total Hip Arthroplasty

TypeinterventionalSponsorClinical Center of VojvodinaRan2026 to 2026Enrolled90ConditionsWound Healing Time, Total Hip Arthroplasty (THA)ArmsVACUTEX™ wound dressing, Octenisept® wound care dressing
3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Pooled it
  5. Pooled it
  6. Trial
  7. Advancing infection therapy: the role of novel menthol-based antimicrobials.Journal of enzyme inhibition and medicinal chemistry · 2026
    Article
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  9. Review
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  13. Bioactivity-Guided Isolation of Stigmasterol fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniela S Masson-MeyersMarquette University School of Dentistry, Milwaukee, Wisconsin, USA.ORCID 0000-0002-3195-4099
Thiago A M AndradeDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0003-3788-2847
Guilherme F CaetanoDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0002-4418-1080
Francielle R GuimaraesDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0003-3679-3316
Marcel N LeiteDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0002-2121-8688
Saulo N LeiteDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0001-9745-6212
Marco Andrey C FradeDivision of Dermatology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.ORCID 0000-0003-2700-5971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing studies are intricate, mainly because of the multifaceted nature of the wound environment and the complexity of the healing process, which integrates a variety of cells and repair phases, including inflammation, proliferation, reepithelialization and remodelling. There are a variety of possible preclinical models, such as in mice, rabbits and pigs, which can be used to mimic acute or impaired for example, diabetic and nutrition-related wounds. These can be induced by many different techniques, with excision or incision being the most common. After determining a suitable model for a study, investigators need to select appropriate and reproducible methods that will allow the monitoring of the wound progression over time. The assessment can be performed by non-invasive protocols such as wound tracing, photographic documentation (including image analysis), biophysical techniques and/or by invasive protocols that will require wound biopsies. In this article, we provide an overview of some of the most often needed and used: (a) preclinical/animal models including incisional, excisional, burn and impaired wounds; (b) methods to evaluate the healing progression such as wound healing rate, wound analysis by image, biophysical assessment, histopathological, immunological and biochemical assays. The aim is to help researchers during the design and execution of their wound healing studies.

Indexed as

Wound HealingAnimalsCell DifferentiationCell MovementCell ProliferationCells, CulturedDisease Models, AnimalFibroblastsHumansKeratinocytesSignal TransductionSkincutaneous wound modelsexperimental animal modelsin vivo modelsskin ulcertissue repairwound healing

Identifiers

PMID32227524
PMCPMC7306904

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.