Evidence map›Paper›PMID 32227447›Full record

ArticleJournal of diabetes investigation2020

Alcohol-induced impaired insulin secretion in a Japanese population: 5-year follow up in the Gifu Diabetes Study.

Natsumi Ueda, Mayumi Yamamoto, Mitsuhiro Nakamura, Yumi Motooka, Yoko Nakayama, Yukiko Nonoyama, Shino Oba, Yukio Horikawa, Chisato Nagata, Daisuke Yabe and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Natsumi UedaLaboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan.
Mayumi YamamotoHealth Administration Center, and United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.ORCID https://orcid.org/0000-0002-5603-6825
Mitsuhiro NakamuraLaboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan.ORCID https://orcid.org/0000-0002-5062-5522
Yumi MotookaLaboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan.
Yoko NakayamaLaboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, Japan.
Yukiko NonoyamaDepartment of Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu, Japan.
Shino ObaGraduate School of Health Sciences, Gumma University, Maebashi, Japan.ORCID https://orcid.org/0000-0002-7388-5861
Yukio HorikawaDepartment of Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu, Japan.ORCID https://orcid.org/0000-0001-7268-6871
Chisato NagataDepartment of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Daisuke YabeDepartment of Endocrinology and Metabolism, Gifu University Graduate School of Medicine, Gifu, Japan.
Gifu Diabetes Study Group
Gifu Pharmaceutical University · JPGifu University · JPGifu University Hospital · JPUmma University · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionAlthough moderate alcohol consumption lowers the risk of type 2 diabetes in European populations, the same cannot be assumed for Japanese patients with diabetes related to low insulin secretion rather than resistance. We aimed to evaluate the effects of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations. MATERIALS AND

methodsThis retrospective study randomly enrolled 452 men and 659 women aged 40-78 years in 2005 (Gifu, Japan). The participants completed a 75-g oral glucose tolerance test and medical questionnaire. The homeostasis model assessment of insulin resistance, homeostasis model assessment of β-cell function and insulinogenic index were used to estimate insulin sensitivity and secretion. The relationships between alcohol consumption and these parameters were analyzed using logistic regression after adjusting for potential confounders. The 5-year changes in hemoglobin A1c levels were also evaluated.

resultsThe adjusted odds ratios for elevated homeostasis model assessment of β-cell function values (<40%) in the 0-19.9 g/day, 20.0-39.9 g/day and ≥ 40 g/day alcohol consumption groups were 0.98, 1.46 and 2.68, respectively. Alcohol consumption induced a significant decrease in the insulin secretion level among the ≥40 g/day drinkers, especially in men. However, there was no risk of increased insulin resistance based on the homeostasis model assessment of insulin resistance (<2.5) results. The 5-year risk of elevated hemoglobin A1c levels (≥6.5%) was increased according to increase in alcohol consumption in both men and women.

conclusionsDaily alcohol consumption was associated with reduced insulin secretion and an increased diabetes development risk in Japanese populations.

Indexed as

Insulin SecretionAdultAgedAlcohol DrinkingBiomarkersDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlucose IntoleranceHumansJapanMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsBiomarkersAlcohol consumptionInsulin secretionJapanese

Identifiers

PMID32227447
PMCPMC7477527
OpenAlexW3013063223

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.