Evidence map›Paper›PMID 32227433›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2020

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells.

John S House, Evangelia Bouzos, Kira M Fahy, Victorino Miguel Francisco, Dillon T Lloyd, Fred A Wright, Alison A Motsinger-Reif, Prashanth Asuri, Korin E Wheeler

Open access · greenAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Assessing the Potential ofMolecules (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

John S HouseBioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.
Evangelia BouzosDepartment of Bioengineering, Santa Clara University, Santa Clara, CA, 95053, USA.
Kira M FahyDepartment of Chemistry and Biochemistry, Santa Clara University, Santa Clara, CA, 95053, USA.
Victorino Miguel FranciscoDepartment of Bioengineering, Santa Clara University, Santa Clara, CA, 95053, USA.
Dillon T LloydBioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.
Fred A WrightBioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.
Alison A Motsinger-ReifBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Prashanth AsuriDepartment of Bioengineering, Santa Clara University, Santa Clara, CA, 95053, USA.
Korin E WheelerDepartment of Chemistry and Biochemistry, Santa Clara University, Santa Clara, CA, 95053, USA.ORCID 0000-0002-4711-5062
Santa Clara University · USNorth Carolina State University · USNational Institute of Environmental Health Sciences · US

Funding

Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2M
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damageR01ES029911 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI RUSYN, IVAN, THREADGILL, DAVID W. · 2019 to 2023
$3.3M
Peptide probes of nanomaterial protein corona dynamics and biological responseR15ES025929 · NIEHS · SANTA CLARA UNIVERSITY · PI WHEELER, KORIN EVELYN · 2016 to 2016
$374k
NIEHS NIH HHS P42 ES027704NIEHS NIH HHS R01 ES029911NIEHS NIH HHS R15 ES025929
6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are widely incorporated into consumer and biomedical products for their antimicrobial and plasmonic properties with limited risk assessment of low-dose cumulative exposure in humans. To evaluate cellular responses to low-dose AgNP exposures across time, human liver cells (HepG2) are exposed to AgNPs with three different surface charges (1.2 µg mL

Indexed as

Gene ExpressionHepatocytesMetal NanoparticlesSilverHumansSurface PropertiesTime FactorsSilvernanotoxicitysilver nanoparticlestranscriptomics

Identifiers

PMID32227433
PMCPMC7446734
OpenAlexW3013135513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.