ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2020
Optical coherence tomography for the investigation of skin adaptation to mechanical stress.
Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Quantification of Skin Adaptation to Lower-Limb Prosthesis Use Through Optical Coherence Tomography Angiography and Thermal Imaging: A Review.Bioengineering (Basel, Switzerland) · 2026Review
- A Device for Characterizing Skin Physiological Response to Mechanical Loading in Transtibial Prosthesis Users.Sensors (Basel, Switzerland) · 2026Article
- Optical coherence tomography and histological assessment of cutaneous vasculature and neural changes in long-term smokers: an exploratory study.Scientific reports · 2026Article
- Single-capillary endothelial dysfunction resolved by optoacoustic mesoscopy.Light, science & applications · 2026Article
- Skin adaptation in lower limb amputees assessed through Raman spectroscopy and mechanical characterization.Journal of the Royal Society, Interface · 2025Article
- Thermal imaging for characterization of skin adaptation in prosthesis users.Medical engineering & physics · 2025Article
- Testing the Reliability of Optical Coherence Tomography to Measure Epidermal Thickness and Distinguish Volar and Nonvolar Skin.JID innovations : skin science from molecules to population health · 2024Article
- A review of musculoskeletal adaptations in individuals following major lower-limb amputation.Journal of musculoskeletal & neuronal interactions · 2022Review
- Quantifying skin sensitivity caused by mechanical insults: A review.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Review
- Optical coherence tomography for the investigation of skin adaptation in lower limb prosthesis users.Journal of prosthetics and orthotics : JPO · 2021Article
- Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography.Scientific reports · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSkin breakdown due to limb-socket interface stress is a significant problem for lower limb prosthesis users. While it is known that skin can adapt to stress to become more resistant to breakdown, little is understood about skin adaptation and few methods exist to noninvasively investigate it. In this study, we present novel, noninvasive imaging methods using Optical Coherence Tomography (OCT) to assess key features of the cutaneous microvasculature that may be involved in skin adaptation. MATERIALS AND
methodsEight able-bodied participants wore a modified below-knee prosthetic socket for two weeks to stress the skin of their lower limb. Two OCT-based imaging tests were used to assess the function and structure, respectively, of the cutaneous microvasculature at multiple time points throughout the socket wear protocol.
resultsA measurable reactive hyperemia response was reliably induced in the skin of study participants in the vascular function assessment test. The vascular structure assessment demonstrated excellent field-of-view repeatability, providing rich data sets of vessel structure. No statistically significant differences were found in any of the measurements when compared between time points of the adaptation protocol. The participants' limbs were likely not stressed enough by the able-bodied socket to induce measurable skin adaptation.
conclusionThis study introduced new techniques to investigate skin adaptation to mechanical stress. If the key limitations are addressed, these methods have the potential to provide insight into the function and structure of the cutaneous microvasculature that previously could not be attained noninvasively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.