SynthesisBlood advances2020
Diagnosis of deep vein thrombosis of the lower extremity: a systematic review and meta-analysis of test accuracy.
Synthesis in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Design-related bias in studies investigating diagnostic tests for venous thromboembolic diseases: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Systematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis.Blood advances · 2020Pooled it
- Assessing the content and quality of deep vein thrombosis on Bilibili, TikTok, and YouTube: a cross-sectional study.Thrombosis journal · 2026Article
- The association between body mass index and lower extremity deep venous abnormalities identified by computed tomography venography.Frontiers in public health · 2026Article
- Development and Validation of a Nomogram for Predicting Postoperative Deep Vein Thrombosis Risk in Patients After Laparoscopic Partial Nephrectomy.Cancer management and research · 2026Article
- Clinical Profile of Patients Admitted With Venous Thrombosis to a Tertiary Care Hospital in India.Cureus · 2026Article
- Latent profile analysis of medication adherence in lower extremity deep venous thrombosis-cross-sectional study.PloS one · 2026Article
- Total and extracellular vesicle-bound plasma P-selectin as diagnostic biomarkers for acute deep vein thrombosis.Research and practice in thrombosis and haemostasis · 2025Article
- Point-of-Care Ultrasound in the Diagnosis of Hematoma Mimicking Deep Vein Thrombosis: A Case Report.Cureus · 2025Article
- Proximal venous ultrasound with risk stratification safely excludes deep venous thrombosis in emergency department routine care: an observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Analysis of the current status and influencing factors of LEDVT in patients with acute hemorrhagic stroke.Medicine · 2025Article
- Article
- Value of clinical review for AI-guided deep vein thrombosis diagnosis with ultrasound imaging by non-expert operators.NPJ digital medicine · 2025Article
- Establishing a prediction model for lower extremity deep venous thrombosis in emergency inpatients in the post epidemic era.Frontiers in surgery · 2025Article
- Development and comparative evaluation of machine learning models for predicting lower extremity deep vein thrombosis in gastrointestinal cancer patients using multicenter longitudinal clinical data.Frontiers in surgery · 2025Article
- Platelet-to-lymphocyte ratio as a predictor of preoperative venous thrombosis in femoral fracture patients: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Complement activation assessed by C3bc and C5b-9 terminal complex as diagnostic biomarkers for deep vein thrombosis.PloS one · 2025Article
- Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis.Research and practice in thrombosis and haemostasis · 2025Article
- Evaluating the benefits of machine learning for diagnosing deep vein thrombosis compared with gold standard ultrasound: a feasibility study.BJGP open · 2024Article
- Clinical significance and underlying mechanism of long non-coding RNA SNHG12 in lower extremity deep venous thrombosis.Clinical and translational science · 2024Article
Corrections and comments
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Authors and funding
28 authors at 13 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep vein thrombosis (DVT) of the lower extremities can be associated with significant morbidity and may progress to pulmonary embolism and postthrombotic syndrome. Early diagnosis and treatment are important to minimize the risk of these complications. We systematically reviewed the accuracy of diagnostic tests for first-episode and recurrent DVT of the lower extremities, including proximal compression ultrasonography (US), whole leg US, serial US, and high-sensitivity quantitative D-dimer assays. We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings. Two investigators screened and abstracted data. Risk of bias was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation framework. We pooled estimates of sensitivity and specificity. The review included 43 studies. For any suspected DVT, the pooled estimates for sensitivity and specificity of proximal compression US were 90.1% (95% confidence interval [CI], 86.5-92.8) and 98.5% (95% CI, 97.6-99.1), respectively. For whole-leg US, pooled estimates were 94.0% (95% CI, 91.3-95.9) and 97.3% (95% CI, 94.8-98.6); for serial US pooled estimates were 97.9% (95% CI, 96.0-98.9) and 99.8% (95% CI, 99.3-99.9). For D-dimer, pooled estimates were 96.1% (95% CI, 92.6-98.0) and 35.7% (95% CI, 29.5-42.4). Recurrent DVT studies were not pooled. Certainty of evidence varied from low to high. This systematic review of current diagnostic tests for DVT of the lower extremities provides accuracy estimates. The tests are evaluated when performed in a stand-alone fashion, and in a diagnostic pathway. The pretest probability of DVT often assessed by a clinical decision rule will influence how, together with sensitivity and specificity estimates, patients will be managed.
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