Evidence map›Paper›PMID 32227211›Full record

ArticleBlood advances2020

Late infectious complications in hematopoietic cell transplantation survivors: a population-based study.

Aimee M Foord, Kara L Cushing-Haugen, Michael J Boeckh, Paul A Carpenter, Mary E D Flowers, Stephanie J Lee, Wendy M Leisenring, Beth A Mueller, Joshua A Hill, Eric J Chow

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06118853 (Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06118853 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2023 to 2025Enrolled35ConditionsHematopoietic Stem Cell Transplantation, Bone Marrow TransplantationArmsyoga or gentle massage plus standard treatment for HSCT
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Managing Invasive Fungal Infections During Allogeneic Hematopoietic Transplantation: A 2025 Update.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  8. Review
  9. Modern-Era Challenges in the Clinical Management of Graft-Versus-Host Disease.Advances in experimental medicine and biology · 2025
    Review
  10. Assessing the Predictive Value of Methicillin-ResistantOpen forum infectious diseases · 2024
    Article
  11. Review
  12. Article
  13. A Population-Based Study of the Long-Term Risk of Infections Associated With Hospitalization in Childhood Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Observational
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aimee M FoordDepartment of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle, WA.
Kara L Cushing-HaugenPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Michael J BoeckhDepartment of Medicine, University of Washington, Seattle, WA.
Paul A CarpenterDepartment of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle, WA.
Mary E D FlowersDepartment of Medicine, University of Washington, Seattle, WA.
Stephanie J LeeDepartment of Medicine, University of Washington, Seattle, WA.
Wendy M LeisenringPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Beth A MuellerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Joshua A HillDepartment of Medicine, University of Washington, Seattle, WA.
Eric J ChowDepartment of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle, WA.
University of Washington · USSeattle Children's Hospital · USFred Hutch Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Geoffrey Roger HILL · 1985 to 2026
$128.4M
Infections in Hematopoietic Cell Transplant RecipientsK24HL093294 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J · 2009 to 2019
$1.5M
Determinants of late cardiovascular morbidity among survivors of hematopoietic ceK07CA151775 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHOW, ERIC JESSEN · 2011 to 2015
$755k
Analysis of Morbidity and Mortality Among Hematopoietic Cell Transplantation SurvR03CA167451 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHOW, ERIC JESSEN · 2013 to 2014
$173k
SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAMN01CN067009 · CN · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID B · 1996 to 1997
–
NCI NIH HHS HHSN261201000121CNCI NIH HHS K07 CA151775NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035142NCI NIH HHS P01 CA018029NCI NIH HHS R03 CA167451NHLBI NIH HHS K24 HL093294
6 · The paper itself

Abstract

Few studies have compared the incidence of infections occurring ≥2 years after hematopoietic cell transplant (HCT) with other cancer patients and the general population. In this study, ≥2-year HCT survivors who were Washington residents treated from 1992 through 2009 (n = 1792; median age, 46 years; 52% allogeneic; 90% hematologic malignancies) were matched to individuals from the state cancer registry (n = 5455, non-HCT) and driver's license files (n = 16 340; Department of Licensing [DOL]). Based on hospital and death registry codes, incidence rate ratios (IRRs; 95% confidence interval [CI]) of infections by organism type and organ system were estimated using Poisson regression. With 7-year median follow-up, the incidence rate (per 1000 person-years) of all infections was 65.4 for HCT survivors vs 39.6 for the non-HCT group (IRR, 1.6; 95% CI, 1.3-1.9) and 7.2 for DOL (IRR, 10.0; 95% CI, 8.3-12.1). Bacterial and fungal infections were each 70% more common in HCT vs non-HCT cancer survivors (IRR, 1.7; P < .01), whereas the risk for viral infection was lower (IRR, 1.4; P = .07). Among potentially vaccine-preventable organisms, the IRR was 3.0 (95% CI, 2.1-4.3) vs the non-HCT group. Although the incidences of all infections decreased with time, the relative risk in almost all categories remained significantly increased in ≥5-year HCT survivors vs other groups. Risk factors for late infection included history of relapse and for some infections, history of chronic graft-versus-host disease. Providers caring for HCT survivors should maintain vigilance for infections and ensure adherence to antimicrobial prophylaxis and vaccination guidelines.

Indexed as

Graft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansMiddle AgedNeoplasm Recurrence, LocalSurvivors

Identifiers

PMID32227211
PMCPMC7160274
OpenAlexW3013942211

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.