Evidence map›Paper›PMID 32226812›Full record

ArticleData in brief2020

RNA-seq data of soleus muscle tissue after spinal cord injury under conditions of inactivity and applied exercise.

Julia H Chariker, Morgan Sharp, Sujata Saraswat Ohri, Cynthia Gomes, Fiona Brabazon, Kathryn A Harman, Scott R Whittemore, Jeffrey C Petruska, David Sk Magnuson, Eric C Rouchka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Julia H CharikerDepartment of Neuroscience Training, University of Louisville, 522 East Gray St., Louisville, KY, 40202, USA.
Morgan SharpKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Sujata Saraswat OhriKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Cynthia GomesDepartment of Anatomical Sciences and Neurobiology, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Fiona BrabazonKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Kathryn A HarmanKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Scott R WhittemoreKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Jeffrey C PetruskaKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
David Sk MagnusonKentucky Spinal Cord Injury Research Center, University of Louisville, 511 South Floyd St., Louisville, KY, 40202, USA.
Eric C RouchkaKentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, 522 East Gray St., Louisville, KY, 40202, USA.
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Propriopsinal neuron function in normal and post-SCI locomotionR01NS112304 · NINDS · UNIVERSITY OF LOUISVILLE · PI Simon Michael Danner, David SK Magnuson · 2021 to 2026
$3.0M
Mechanisms controlling distinct modes of adult axon growthR01NS094741 · NINDS · UNIVERSITY OF LOUISVILLE · PI PETRUSKA, JEFFREY C · 2015 to 2019
$1.7M
Re-training locomotor circuitry in a rat model of spinal cord injuryR56NS052292 · NINDS · UNIVERSITY OF LOUISVILLE · PI MAGNUSON, DAVID SK · 2011 to 2011
$373k
NIGMS NIH HHS P20 GM103436NINDS NIH HHS R01 NS094741NINDS NIH HHS R01 NS112304NINDS NIH HHS R56 NS052292
6 · The paper itself

Abstract

Reduced muscle mass and increased fatiguability are major complications after spinal cord injury (SCI), and often hinder the rehabilitation efforts of patients. Such detriments to the musculoskeletal system, and the concomitant reduction in level of activity, contribute to secondary complications such as cardiovascular disease, diabetes, bladder dysfunction and liver damage. As a result of decreased weight-bearing capacity after SCI, muscles undergo morphological, metabolic, and contractile changes. Recent studies have shown that exercise after SCI decreases muscle wasting and reduces the burden of secondary complications. Here, we describe RNA sequencing data for detecting chronic transcriptomic changes in the rat soleus after SCI at two levels of injury severity, under conditions of restricted in-cage activity and two methods of applied exercise, swimming or shallow water walking. We demonstrate that the sequenced data are of good quality and show a high alignment rate to the

Indexed as

ExerciseInactivitySCISoleus muscleSpinal cord injuryTranscriptomics

Identifiers

PMID32226812
PMCPMC7093805
OpenAlexW2998550431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.