A young child with HIV and unsteady gait: A case report.

Nadine Yazbeck, Yolla Youssef, Rima Hanna-Wakim

Open access · goldAbstract readCase Reports

In one paragraph

Article in IDCases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 83% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nadine YazbeckDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Yolla YoussefDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Rima Hanna-WakimDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

American University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. CASE PRESENTATION: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance.

conclusionsThe excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity.

Indexed as

3TC, LamivudineADH, alcohol dehydrogenaseALDH, aldehyde dehydrogenaseART, antiretroviral therapyAZT, ZidovudineCNS, central nervous systemHIVLopinavir-ritonavirLPV/r, Lopinavir/ritonavirPI, protease inhibitorUnsteady gaitWHO, World Health Organization

Identifiers

PMID32226753

DOI10.1016/j.idcr.2019.e00643

PMCPMC7093736

OpenAlexW2989233019

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.