ArticleTheranostics2020
Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study.
Abstract readClinical Trial, Phase I
In one paragraph
Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed.
- Near-infrared fluorescence imaging-guided surgery using cRGD-ZW800 to improve surgical resection margins in oral cancer: a phase I/II feasibility trial.Nature communications · 2026Trial
- Intraoperative fluorescence-guided fresh frozen sectioning for margin control in head and neck cancer: phase 2 clinical trial.Nature communications · 2026Trial
- Trial
- EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial.Nature communications · 2023Trial
- Epidermal Growth Factor Receptor-Targeted Fluorescence Molecular Imaging for Postoperative Lymph Node Assessment in Patients with Oral Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Trial
- Article
- Clinical fluorescent probes: mechanisms, advantages and inspirations.Chemical science · 2026Review
- A GLUT1-targeted peptide tracer for precision molecular imaging of esophageal squamous cell carcinoma: from early detection to intraoperative margin assessment.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- ENDOSWIR clinical proof of concept: a reflectance-based multispectral imaging device for head and neck cancer detection.Biomedical optics express · 2026Article
- Targeting EpCAM expression via near-infrared fluorescent antibodies enables microscopic delineation of primary and recurrent HNSCC.BMC cancer · 2026Article
- Antibody-functionalized gold nanospheres for multimodal imaging.Scientific reports · 2026Article
- Photosensitizer-Antibody Conjugates (PhotoBodies): Emerging Frontiers in the Field of Theranostics.Pharmaceutical research · 2026Review
- Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging.EJNMMI radiopharmacy and chemistry · 2025Article
- Epidermal growth factor receptor-targeted near-infrared probe cetuximab-IRDye800CW enables stable and tumor-specific fluorescence imaging in colorectal cancer models.Journal of biomedical optics · 2025Article
- Compatibility of fast tissue clearing with targeted fluorescence imaging and pathology analysis using clinical head and neck cancer biopsies.Scientific reports · 2025Article
- Near-Infrared-II Fluorescence Imaging of Tumors with Organic Small-Molecule Fluorophores.Sensors (Basel, Switzerland) · 2025Review
- Intraoperative fluorescence in solid head and neck cancer: A scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Development of Clinical-Grade Durvalumab-680LT and Nivolumab-800CW for Multispectral Fluorescent Imaging of the PD-1/PD-L1 Axis of the Immune Checkpoint Pathway.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting.Molecular diagnosis & therapy · 2025Review
- Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy.Chemical reviews · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Floris Jan VoskuilDepartment of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Steven Jakob de JonghDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, the Netherlands.
Wouter Tjerk Rudolph HooghiemstraDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, the Netherlands.
Matthijs David LinssenDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, the Netherlands.
Pieter Jan SteinkampDepartment of Surgery and Medical Imaging Center, University of Groningen, University Medical Center Groningen, the Netherlands.
Sebastiaan Antonius Hendrik Johannes de VisscherDepartment of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Kees-Pieter SchepmanDepartment of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Sjoerd Geert EliasDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, The Netherlands.
Gert-Jan MeersmaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, the Netherlands.
Pascal Klaas Christiaan JonkerDepartment of Surgery and Medical Imaging Center, University of Groningen, University Medical Center Groningen, the Netherlands.
Jan Johannes DoffDepartment of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands.
Annelies Jorritsma-SmitDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, The Netherlands.
Wouter Bastiaan NagengastDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, the Netherlands.
Bert van der VegtDepartment of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands.
Dominic James RobinsonCenter for Optical Diagnostics and Therapy, Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Gooitzen Michell van DamDepartment of Surgery and Medical Imaging Center, University of Groningen, University Medical Center Groningen, the Netherlands.
Max Johannes Hendrikus WitjesDepartment of Oral & Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC) surgeries, as intraoperative techniques for
Indexed as
Optical ImagingSurgery, Computer-AssistedAgedAged, 80 and overAntineoplastic Agents, ImmunologicalBenzenesulfonatesCetuximabCohort StudiesFemaleFluorescent DyesHead and Neck NeoplasmsHumansIndolesMaleMargins of ExcisionMiddle AgedAntineoplastic Agents, ImmunologicalBenzenesulfonatesCetuximabFluorescent DyesIndolesIRDye 800CWcetuximab-800CWfluorescence-guided imaginghead and neck cancerintrinsic fluorescenceMDSFR/SFF spectroscopy
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.