Evidence map›Paper›PMID 32226525›Full record

ArticleTheranostics2020

PET Imaging of Liposomal Glucocorticoids using

Peter J Gawne, Fiona Clarke, Keren Turjeman, Andrew P Cope, Nicholas J Long, Yechezkel Barenholz, Samantha Y A Terry, Rafael T M de Rosales

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Hydroxyquinoline-functionalised aza-crown macrocycles for lanthanide coordination.Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. PET Imaging of Small Extracellular VesiclesBioconjugate chemistry · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Imaging techniques in nanomedical research.European journal of histochemistry : EJH · 2020
    Article
  18. A kit formulation for the preparation of [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Peter J GawneSchool of Imaging Sciences & Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.
Fiona ClarkeCentre for Inflammation Biology and Cancer Immunology, King's College London, New Hunt's House, London, SE1 1UL, UK.
Keren TurjemanLaboratory of Membrane and Liposome Research, Department of Biochemistry,Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Andrew P CopeCentre for Inflammation Biology and Cancer Immunology, King's College London, New Hunt's House, London, SE1 1UL, UK.
Nicholas J LongDepartment of Chemistry, MSRH, Imperial College London, White City Campus, W12 0BZ, London, UK.
Yechezkel BarenholzLaboratory of Membrane and Liposome Research, Department of Biochemistry,Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Samantha Y A TerrySchool of Imaging Sciences & Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.
Rafael T M de RosalesSchool of Imaging Sciences & Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.
St Thomas' Hospital · GBHadassah Medical Center · ILKing's College London · GBImperial College London · GB

Funding

Cancer Research UK A16463Wellcome Trust
6 · The paper itself

Abstract

The encapsulation of Glucocorticoids (GCs) into long-circulating liposomes (LCLs) is a proven strategy to reduce the side effects of glucocorticoids and improve the treatment of inflammatory diseases, such as rheumatoid arthritis (RA). With the aim of supporting the development of GC-loaded LCLs, and potentially predict patient response to therapy clinically, we evaluated a direct PET imaging radiolabelling approach for preformed GC-LCLs in an animal model of human inflammatory arthritis.

Indexed as

AnimalsArthritis, RheumatoidDisease Models, AnimalDrug Delivery SystemsGlucocorticoidsInflammationLiposomesMiceNanomedicinePositron-Emission TomographyPositron Emission Tomography Computed TomographyPrecision MedicineTissue DistributionGlucocorticoidsLiposomesIn vivo Liposome ImagingNanomedicinePersonalised NanomedicinePositron Emission TomographyRheumatoid Arthritis

Identifiers

PMID32226525
PMCPMC7086351
OpenAlexW3012688995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.