Evidence map›Paper›PMID 32226524›Full record

ReviewTheranostics2020

Aptamer-guided extracellular vesicle theranostics in oncology.

Phuong H-L Tran, Dongxi Xiang, Tuong N-G Nguyen, Thao T-D Tran, Qian Chen, Wang Yin, Yumei Zhang, Lingxue Kong, Andrew Duan, Kuisheng Chen and 7 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Phuong H-L TranSchool of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria, Australia.
Dongxi XiangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 77 Avenue Louise Pasteur, Boston, MA 02115, USA.
Tuong N-G NguyenSchool of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria, Australia.
Thao T-D TranDepartment for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Qian ChenTranslational Medical Center, The Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, China, 100853.
Wang YinSchool of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria, Australia.
Yumei ZhangSchool of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria, Australia.
Lingxue KongInstitute for Frontier Materials, Deakin University, Waurn Ponds, Victoria, 3216, Australia.
Andrew DuanSchool of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, 27 Rainforest Walk, Clayton VIC 3800, Australia.
Kuisheng ChenDepartment of Pathology, The First Affiliated Hospital, Zhengzhou University, He'nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China.
Miomio SunDepartment of Pathology, The First Affiliated Hospital, Zhengzhou University, He'nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China.
Yong LiCancer Care Centre, St George Hospital, Kogarah, and St George and Sutherland Clinical School, University of New South Wales, Kensington, NSW, Australia.
Yingchun HouLaboratory of Tumor Molecular and Cellular Biology, College of Life Sciences, Shaanxi Normal University, 620 West Chang'an Avenue, Xi'an, Shaanxi 710119, China.
Yimin ZhuCAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Yongchao MaClinical School, Luohe Medical College, 148, Daxue Road, Luohe City, Henan Province, 462000, China.
Guoqin JiangDepartment of General Surgery, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, P.R. China, 215004.
Wei DuanSchool of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria, Australia.
Deakin University · AUFirst Affiliated Hospital of Zhengzhou University · CNChinese Academy of Sciences · CNMonash University · AUTon Duc Thang University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past decade, the study of exosomes, nanosized vesicles (50-150 nm) released into the extracellular space via the fusion of multivesicular bodies with the plasma membrane, has burgeoned with impressive achievements in theranostics applications. These nanosized vesicles have emerged as key players in homeostasis and in the pathogenesis of diseases owing to the variety of the cargos they can carry, the nature of the molecules packaged inside the vesicles, and the robust interactions between exosomes and target cells or tissues. Accordingly, the development of exosome-based liquid biopsy techniques for early disease detection and for monitoring disease progression marks a new era of precision medicine in the 21

Indexed as

NeoplasmsDrug Delivery SystemsExosomesExtracellular VesiclesHumansMedical OncologyPrecision MedicineSELEX Aptamer Techniqueaptamersexosomesliquid biopsytargetingtheranostics

Identifiers

PMID32226524
PMCPMC7086349
OpenAlexW3008261084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.