Evidence map›Paper›PMID 32226460›Full record

ArticleMolecular & cellular toxicology2019

Ki Hyung Kim, Juil Kim, Jae Yong Han, Yuseok Moon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ki Hyung Kim *1Department of Biomedical Sciences, Biomedical Research Institute, Pusan National University, Yangsan, 50612 Republic of Korea.
Juil Kim *1Department of Biomedical Sciences, Biomedical Research Institute, Pusan National University, Yangsan, 50612 Republic of Korea.
Jae Yong Han4Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826 Republic of Korea.
Yuseok Moon1Department of Biomedical Sciences, Biomedical Research Institute, Pusan National University, Yangsan, 50612 Republic of Korea.
Pusan National University · KRDonggwon Science and Technology University · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsHeavy metals affect various processes in the embryonic development. Embryonic fibroblasts (EFs) play key roles in the innate recognition and wound healing in reproductive tissues.

methodsBased on the relative toxicities of different inorganic metals and inorganic nonmetallic compounds against murine and chicken EF cells, mechanistic estimations were performed based on transcriptomic analyses.

resultsLead (II) acetate induced preferential injuries in the chicken EF and mechanistic analyses using transcriptome revealed that chemokine receptor-associated events are potently involved in metal-induced adverse actions. As an early sentinel of metal exposure, the precision-cut intestine slices (PCIS) induced the expression of chemokines including CXCLi1 or CXCLi2, which were potent gut-derived factors that activate chemokine receptors in reproductive organs after circulation.

conclusionEF-selective metals can be estimated to trigger the chemokine circuit in the gut-reproductive axis of chickens. This

Indexed as

Chemokine receptorEmbryonic fibroblastsHeavy metalsPCIS

Identifiers

PMID32226460
PMCPMC7097086
OpenAlexW2978899476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.