Evidence map›Paper›PMID 32226459›Full record

ArticleMolecular & cellular toxicology2019

Specific elimination of coxsackievirus B3 infected cells with a protein engineered toxin-antitoxin system.

Jung-Ho Park, Jin-Ho Park, Wonho Choi, Byung-Kwan Lim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jung-Ho Park *1Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28120 Republic of Korea.
Jin-Ho Park *2Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, 28024 Republic of Korea.
Wonho Choi1Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28120 Republic of Korea.
Byung-Kwan Lim2Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, 28024 Republic of Korea.
Jungwon University · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsCoxsackievirus B3 (CVB3) is a member of the family

methodsWe modified the MazE-MazF antitoxin-toxin system of

resultsThe incubation of 2A proteases with the fusion proteins induced cleavage between the MazE and MazF fragments from the fusion proteins; the subsequent release of MazF significantly inhibited virus replication. Additionally, we note that, CVB3 infected HeLa cells quickly died through a MazF toxin mediated effect before virus protein expression.

conclusionThese findings suggest that the MazEF fusion protein has a strong potential to be developed as an anti-virus therapy following CVB3 infection.

Indexed as

AntitoxinCardiotropicCoxsackievirusMazEFPolyproteinProteases

Identifiers

PMID32226459
PMCPMC7097453
OpenAlexW2977603574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.