Evidence map›Paper›PMID 32226390›Full record

ArticleFrontiers in physiology2020

Influence of Positive End-Expiratory Pressure Titration on the Effects of Pronation in Acute Respiratory Distress Syndrome: A Comprehensive Experimental Study.

Gaetano Scaramuzzo, Lorenzo Ball, Fabio Pino, Lucia Ricci, Anders Larsson, Claude Guérin, Paolo Pelosi, Gaetano Perchiazzi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Gaetano ScaramuzzoDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Lorenzo BallDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Fabio PinoHedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Lucia RicciDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Anders LarssonHedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Claude GuérinGroupement Hospitalier Centre, Médecine Intensive Réanimation, Hospices Civils de Lyon, Lyon, France.
Paolo PelosiDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
Gaetano PerchiazziHedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
University of Genoa · ITOspedale Policlinico San Martino · ITUniversité Claude Bernard Lyon 1 · FRUniversity of Ferrara · ITUppsala University · SEUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal model of ARDS, if the PEEP titration method may influence the effect of prone position on oxygenation and lung protection. In a crossover study in 10 piglets with a two-hit injury ARDS model, we set the "best PEEP" according to the ARDS Network low-PEEP table (BP

Indexed as

acute respiratory distress syndromepositive end-expiratory pressureprone positioningtitrationventilator-induced lung injury

Identifiers

PMID32226390
PMCPMC7080860
OpenAlexW3011510365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.