Evidence map›Paper›PMID 32226338›Full record

ReviewThe Yale journal of biology and medicine2020

Recent Advances in Studies of Skin Color and Skin Cancer.

Greggory S LaBerge, Eric Duvall, Zachary Grasmick, Kay Haedicke, Anjela Galan, Jesse Leverett, Sudhir Baswan, Sunghan Yim, John Pawelek

Open access · greenAbstract readReview
In one paragraph

Review in The Yale journal of biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Brown MacroalgaeMolecules (Basel, Switzerland) · 2022
    Article
  12. 3D skin bioprinting: future potential for skin regeneration.Postepy dermatologii i alergologii · 2022
    Review
  13. Trends in Office Visits for the Five Most Common Skin Diseases in the United States.The Journal of clinical and aesthetic dermatology · 2022
    Review
  14. Article
  15. The Impact of the Circadian Clock on Skin Physiology and Cancer Development.International journal of molecular sciences · 2021
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Greggory S LaBergeHuman Medical Genetics and Genomics Program, University of Colorado School of Medicine, Denver, CO.
Eric DuvallDenver Police Crime Lab-Forensics and Evidence Division, Denver, CO.
Zachary GrasmickDepartment of Pathology, University of Colorado AMC, Denver, CO.
Kay HaedickeDepartment of Internal Medicine Section of Medical Oncology and the Yale Cancer Center, Yale School of Medicine, New Haven, CT.
Anjela GalanDepartment of Dermatology and The Yale Cancer Center, Yale School of Medicine, New Haven, CT.
Jesse LeverettThe Amway Corporation, Ada, MI.
Sudhir BaswanThe Amway Corporation, Ada, MI.
Sunghan YimThe Amway Corporation, Ada, MI.
John PawelekDepartment of Dermatology and The Yale Cancer Center, Yale School of Medicine, New Haven, CT.
Amway (United States) · USYale Cancer Center · USPolice Department · LTUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between skin color and skin cancer is well established: the less melanin in one's skin the greater the risk for developing skin cancer. This review is in two parts. First, we summarize the current understanding of the cutaneous pigmentary system and trace melanin from its synthesis in the pigment cell melanosomes through its transfer to keratinocytes. We also present new methods for reducing melanin content in hyper-pigmented areas of skin such as solar lentigenes, melasma, and post-inflammatory hyperpigmentation. Second, we present evidence that at least one mechanism for the development of metastatic melanoma and other solid tumors is fusion and hybridization of leucocytes such as macrophages with primary tumor cells. In this scenario, hybrid cells express both the chemotactic motility of the leucocyte and the de-regulated cell division of the tumor cell, causing the cells to migrate a deadly journey to lymph nodes, distant organs, and tissues.

Indexed as

HyperpigmentationSkin NeoplasmsHumansMelaninsSkin PigmentationMelaninscytidine as melanin inhibitorleucocyte-tumor cell hybridsmelanin transferskin cancerskin color

Identifiers

PMID32226338
PMCPMC7087065
OpenAlexW3013982040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.