Evidence map›Paper›PMID 32226330›Full record

ArticleThe Yale journal of biology and medicine2020

Crystal Structure of Keratin 1/10(C401A) 2B Heterodimer Demonstrates a Proclivity for the C-Terminus of Helix 2B to Form Higher Order Molecular Contacts.

Ivan B Lomakin, Alexander J Hinbest, Minh Ho, Sherif A Eldirany, Christopher G Bunick

Open access · greenAbstract read
In one paragraph

Article in The Yale journal of biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Recent insight into intermediate filament structure.Current opinion in cell biology · 2021
    Review
  6. Article
  7. Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain.International journal of molecular sciences · 2020
    Article
  8. The Interface between Keratin Structurotype and Human Disease.Structure (London, England : 1993) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ivan B LomakinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
Alexander J HinbestDepartment of Dermatology, Yale University, New Haven, CT.
Minh HoDepartment of Dermatology, Yale University, New Haven, CT.
Sherif A EldiranyDepartment of Dermatology, Yale University, New Haven, CT.
Christopher G BunickDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Determining Structure and Function of Human Skin Barrier Proteins Using X-ray CrystallographyK08AR070290 · NIAMS · YALE UNIVERSITY · PI BUNICK, CHRISTOPHER GERARD · 2016 to 2020
$754k
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS K08 AR070290
6 · The paper itself

Abstract

We previously determined the crystal structure of the wild-type keratin 1/10 helix 2B heterodimer at 3.3 Å resolution. We proposed that the resolution of the diffraction data was limited due to the crystal packing effect from keratin 10 (K10) residue Cys401. Cys401

Indexed as

Intermediate FilamentsKeratin-1Amino Acid SequenceCytoskeletal ProteinsCytoskeletonDisulfidesGenetic LinkageHumansKeratinocytesMutationPeptide FragmentsProtein ConformationCytoskeletal ProteinsDisulfidesKeratin-1KRT1 protein, humanPeptide Fragmentsassemblydisulfide bondheterodimerintermediate filamentkeratinstructure

Identifiers

PMID32226330
PMCPMC7087056
OpenAlexW3013174537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.