Evidence map›Paper›PMID 32226025›Full record

ArticlePloS one2020

Risk of biliary tract disease in living liver donors: A population-based cohort study.

Shih-Yi Lin, Cheng-Li Lin, Wu-Huei Hsu, I-Kuan Wang, Cheng-Chieh Lin, Long-Bing Jeng, Chia-Hung Kao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shih-Yi LinGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Cheng-Li LinManagement Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Wu-Huei HsuGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
I-Kuan WangGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Cheng-Chieh LinGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Long-Bing JengGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Chia-Hung KaoGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.ORCID 0000-0002-6368-3676
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsWhether living liver donors have a higher risk of biliary tract disease compared with non-donors remains unknown.

methodsData were collected from the Taiwan Longitudinal Health Insurance Database for the 2003-2011 period. The study cohort comprised 1,446 patients aged ≥ 18 years who had served as living liver donors. The primary outcome was the incidence of biliary tract disease. Cox proportional hazards modeling was used to determine the hazard ratios.

resultsThe incidence density rate of biliary tract disease was 13.9-fold higher in the liver donor (LD) cohort than in the non-LD cohort (10.2 vs. 0.71 per 1,000 person-years), with an adjusted hazard ratio (HR) of 14.2 (95% confidence interval [CI] = 7.73-26.1). Stratified by comorbidity, the relative risk of biliary tract disease was higher in the LD cohort than in the non-LD cohort for both patients with or without comorbidity. The incidence density rate of biliary tract disease was significantly higher in the first 3 years (13.5 per 1,000 person-years in the LD cohort). The highest adjusted HR of biliary tract disease for LD patients compared with the non-LD cohort was 22.4 (95% CI = 10.8-46.1) in the follow-up ≤ 3 years.

conclusionLiving liver donors had a higher risk of biliary tract disease compared with non-donors.

Indexed as

AdultBiliary Tract DiseasesCohort StudiesFemaleHumansLiving DonorsMaleMiddle AgedRisk

Identifiers

PMID32226025
PMCPMC7105125
OpenAlexW3013377612

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.