SynthesisPLoS genetics2020
Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.Nature communications · 2025Pooled it
- Weight loss in MASLD restores the balance of liver fatty acid sources.The Journal of clinical investigation · 2025Trial
- A Mendelian randomization-based drug repurposing pipeline: application to lipid traits and coronary artery disease.medRxiv : the preprint server for health sciences · 2026Article
- Genome-wide association study identifies novel and confirms established loci associated with serum lipids levels in Brazilians.Human genetics · 2026Article
- Assessing long-term pleiotropic effects of potential novel triglyceride-lowering medications using variants identified by Mendelian randomization.medRxiv : the preprint server for health sciences · 2025Article
- Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants.Clinical epigenetics · 2025Article
- The breadth and impact of the Global Lipids Genetics Consortium.Current opinion in lipidology · 2025Review
- Empowering genome-wide association studies via a visualizable test based on the regional association score.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Article
- Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.Cell genomics · 2024Article
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.Molecular psychiatry · 2024Article
- Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry.Journal of lipid research · 2024Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Article
- Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants.Annual review of biomedical data science · 2023Review
- Limitations of principal components in quantitative genetic association models for human studies.eLife · 2023Article
- Cholesterol induces inflammation and reduces glucose utilization.Open medicine (Warsaw, Poland) · 2023Article
- Assessment of multi-population polygenic risk scores for lipid traits in African Americans.PeerJ · 2023Article
- Whole genome sequence analysis of blood lipid levels in >66,000 individuals.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 20 institutions in 1 country.
Yao HuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0002-2810-646X
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID 0000-0001-6380-1735
Jeffrey HaesslerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Steven BuyskeDepartment of Statistics and Biostatistics, Rutgers University, New Brunswick, New Jersey, United States of America.ORCID 0000-0001-8539-5416
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0002-8713-4583
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID 0000-0002-3583-8239
Katherine K NishimuraPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0003-3950-4495
Niha ZubairPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Marie VerbanckThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID 0000-0002-1669-572X
Austin T HilliardPalo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, California, United States of America.
Derek KlarinCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0002-4636-5780
Scott M DamrauerEmory Clinical Cardiovascular Research Institute, Atlanta, Georgia, United States of America.ORCID 0000-0001-8009-1632
Yuk-Lam HoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.ORCID 0000-0003-3305-3830
VA Million Veteran Program
Peter W F WilsonEmory Clinical Cardiovascular Research Institute, Atlanta, Georgia, United States of America.
Kyong-Mi ChangCorporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0001-6811-9364
Philip S TsaoDepartment of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.ORCID 0000-0001-7274-9318
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.
Christopher J O'DonnellMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.ORCID 0000-0003-2349-0009
Lauren E PettyThe Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
Jennifer E BelowThe Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.ORCID 0000-0002-6372-6402
Ozan DikilitasDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.ORCID 0000-0002-9906-8608
Daniel J SchaidDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Matthew L KoselDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Gail P JarvikDepartment of Medicine, University of Washington Medical Center, Seattle, Washington, United States of America.ORCID 0000-0002-6710-8708
Qiping FengDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.ORCID 0000-0002-6213-793X
Wei-Qi WeiDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.ORCID 0000-0003-4985-056X
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, Washington, United States of America.ORCID 0000-0003-1108-6164
Frank D MentchCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Berta AlmogueraCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Patrick M SleimanCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.ORCID 0000-0001-9874-8532
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.ORCID 0000-0002-7892-193X
Adolfo CorreaDepartments of Medicine, Pediatrics, and Population Health Science, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.ORCID 0000-0002-9501-600X
Lisa W MartinSchool of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, United States of America.
Martha DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.
Tara C MatiseDepartment of Statistics and Biostatistics, Rutgers University, New Brunswick, New Jersey, United States of America.ORCID 0000-0002-7147-492X
Jose Luis AmbiteInformation Sciences Institute, University of Southern California, Marina del Rey, California, United States of America.
Christopher S CarlsonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0003-0561-3538
Ron DoThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID 0000-0002-3144-3627
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID 0000-0002-8532-5087
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
Chris HaimanKeck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Daniel O StramKeck School of Medicine, University of Southern California, Los Angeles, California, United States of America.ORCID 0000-0001-7099-9022
Lucia A HindorffDivision of Genomic Medicine, NIH National Human Genome Research Institute, Bethesda, Maryland, United States of America.ORCID 0000-0002-4414-3236
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Iona ChengCancer Prevention Institute of California, Fremont, California, United States of America.ORCID 0000-0003-4132-2893
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.ORCID 0000-0001-5666-9318
Fred Hutch Cancer Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · USVA Palo Alto Health Care System · USChildren's Hospital of Philadelphia · USEmory Healthcare · USIcahn School of Medicine at Mount Sinai · USMayo Clinic · USRutgers, The State University of New Jersey · USVanderbilt University Medical Center · USCancer Prevention Institute of California · USGeorge Washington University · USHarvard University · USNorthwestern University · USUniversity of Hawaiʻi at Mānoa · USBroad Institute · USKaiser Permanente Washington Health Research Institute · USMayo Clinic in Florida · USUniversity of Washington Medical Center · USVA Boston Healthcare System · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MFinding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6MVariation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4MOMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3MDNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9MHARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MBLRD VA I01 BX003340BLRD VA I01 BX003362BLRD VA I01 BX004821CSRD VA I01 CX001025NCI NIH HHS HHSN261201800010INCI NIH HHS U01 CA164973NCRR NIH HHS UL1 RR025005NHGRI NIH HHS L30 HG009840NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG006375NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG006388NHGRI NIH HHS U01 HG006389NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG006830NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K01 HL125751NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL142302NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL007734NHLBI NIH HHS T32 HL129982NIA NIH HHS HHSN271201100004CNIDDK NIH HHS R01 DK101855NIH HHS S10 OD020069NIMHD NIH HHS HHSN268201800013IWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Lipid levels are important markers for the development of cardio-metabolic diseases. Although hundreds of associated loci have been identified through genetic association studies, the contribution of genetic factors to variation in lipids is not fully understood, particularly in U.S. minority groups. We performed genome-wide association analyses for four lipid traits in over 45,000 ancestrally diverse participants from the Population Architecture using Genomics and Epidemiology (PAGE) Study, followed by a meta-analysis with several European ancestry studies. We identified nine novel lipid loci, five of which showed evidence of replication in independent studies. Furthermore, we discovered one novel gene in a PrediXcan analysis, minority-specific independent signals at eight previously reported loci, and potential functional variants at two known loci through fine-mapping. Systematic examination of known lipid loci revealed smaller effect estimates in African American and Hispanic ancestry populations than those in Europeans, and better performance of polygenic risk scores based on minority-specific effect estimates. Our findings provide new insight into the genetic architecture of lipid traits and highlight the importance of conducting genetic studies in diverse populations in the era of precision medicine.
Indexed as
Databases, GeneticFemaleGenome-Wide Association StudyGenotypeHumansLipidsMaleMetagenomicsMinority GroupsMultifactorial InheritancePhenotypePolymorphism, Single NucleotideRacial GroupsUnited StatesLipids
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