ArticlePLoS computational biology2020
Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations.PLoS computational biology · 2026Article
- Can we infer excitation-inhibition balance from the spectrum of population activity?Communications biology · 2025Article
- Correction: Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations.PLoS computational biology · 2025Article
- Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson's disease and dystonia.NPJ Parkinson's disease · 2025Article
- Structural constraints on the emergence of oscillations in multi-population neural networks.eLife · 2024Article
- Cortex-wide topography of 1/f-exponent in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- A model description of beta oscillations in the external globus pallidus.Cognitive neurodynamics · 2023Article
- Article
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.PLoS computational biology · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson's disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping these oscillations has remained unclear. In order to uncouple their effects, we studied the dynamics of STN-GPe network using numerical simulations. In particular, we used a neuron model, in which firing rates and spike bursting can be independently controlled. Using this model, we found that while STN firing rate is predictive of oscillations, GPe firing rate is not. The effect of spike bursting in STN and GPe neurons was state-dependent. That is, only when the network was operating in a state close to the border of oscillatory and non-oscillatory regimes, spike bursting had a qualitative effect on the β band oscillations. In these network states, an increase in GPe bursting enhanced the oscillations whereas an equivalent proportion of spike bursting in STN suppressed the oscillations. These results provide new insights into the mechanisms underlying the transient β bursts and how duration and power of β band oscillations may be controlled by an interplay of GPe and STN firing rates and spike bursts.
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