ArticlePLoS computational biology2020
Mechanisms underlying attraction to odors in walking Drosophila.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neural dynamics for working memory and evidence integration during olfactory navigation in Drosophila.Nature communications · 2026Article
- Neural dynamics for working memory and evidence integration during olfactory navigation inbioRxiv : the preprint server for biology · 2025Article
- Inhibitory control explains locomotor statistics in walkingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A vector-based strategy for olfactory navigation inbioRxiv : the preprint server for biology · 2025Article
- Inhibitory control of locomotor statistics in walkingbioRxiv : the preprint server for biology · 2024Article
- Wind gates olfaction-driven search states in free flight.Current biology : CB · 2024Article
- Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.Nature communications · 2023Article
- Temporal novelty detection and multiple timescale integration drive Drosophila orientation dynamics in temporally diverse olfactory environments.PLoS computational biology · 2023Article
- Behavioral algorithms and neural mechanisms underlying odor-modulated locomotion in insects.The Journal of experimental biology · 2023Review
- Adaptation ofeLife · 2022Article
- Article
- TheMolecules and cells · 2022Article
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- A connectome of theeLife · 2021Article
- Correlated decision making across multiple phases of olfactory-guided search in Drosophila improves search efficiency.The Journal of experimental biology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mechanisms that control movements range from navigational mechanisms, in which the animal employs directional cues to reach a specific destination, to search movements during which there are little or no environmental cues. Even though most real-world movements result from an interplay between these mechanisms, an experimental system and theoretical framework for the study of interplay of these mechanisms is not available. Here, we rectify this deficit. We create a new method to stimulate the olfactory system in Drosophila or fruit flies. As flies explore a circular arena, their olfactory receptor neuron (ORNs) are optogenetically activated within a central region making this region attractive to the flies without emitting any clear directional signals outside this central region. In the absence of ORN activation, the fly's locomotion can be described by a random walk model where a fly's movement is described by its speed and turn-rate (or kinematics). Upon optogenetic stimulation, the fly's behavior changes dramatically in two respects. First, there are large kinematic changes. Second, there are more turns at the border between light-zone and no-light-zone and these turns have an inward bias. Surprisingly, there is no increase in turn-rate, rather a large decrease in speed that makes it appear that the flies are turning at the border. Similarly, the inward bias of the turns is a result of the increase in turn angle. These two mechanisms entirely account for the change in a fly's locomotion. No complex mechanisms such as path-integration or a careful evaluation of gradients are necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.