Evidence map›Paper›PMID 32225868›Full record

ArticleOptics express2020

Comparative phase imaging of live cells by digital holographic microscopy and transport of intensity equation methods.

Jeremy M Wittkopp, Ting Chean Khoo, Shane Carney, Kai Pisila, Shahab J Bahreini, Kate Tubbesing, Supriya Mahajan, Anna Sharikova, Jonathan C Petruccelli, Alexander Khmaladze

Open access · goldAbstract readComparative Study
In one paragraph

Article in Optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 28 citations in OpenAlex.

  1. Macromolecular Crowding in Cell Stress and Death.Sub-cellular biochemistry · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jeremy M Wittkopp
Ting Chean Khoo
Shane Carney
Kai Pisila
Shahab J Bahreini
Kate Tubbesing
Supriya Mahajan
Anna Sharikova
Jonathan C Petruccelli
Alexander Khmaladze
University at Albany, State University of New York · USUniversity at Buffalo, State University of New York · US

Funding

A novel phase and spectroscopic imaging technique to evaluate mitochondrial dynamicsR01DA047410 · NIDA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI KHMALADZE, ALEXANDER, MAHAJAN, SUPRIYA DINKAR · 2019 to 2021
$1.1M
NIDA NIH HHS R01 DA047410
6 · The paper itself

Abstract

We describe a microscopic setup implementing phase imaging by digital holographic microscopy (DHM) and transport of intensity equation (TIE) methods, which allows the results of both measurements to be quantitatively compared for either live cell or static samples. Digital holographic microscopy is a well-established method that provides robust phase reconstructions, but requires a sophisticated interferometric imaging system. TIE, on the other hand, is directly compatible with bright-field microscopy, but is more susceptible to noise artifacts. We present results comparing DHM and TIE on a custom-built microscope system that allows both techniques to be used on the same cells in rapid succession, thus permitting the comparison of the accuracy of both methods.

Indexed as

Digital TechnologyAnimalsCell SurvivalCheekFourier AnalysisHolographyHumansMicroscopy

Identifiers

PMID32225868
PMCPMC7347524
OpenAlexW3004190386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.