Evidence map›Paper›PMID 32225122›Full record

ArticleCancers2020

A Nine-Gene Signature for Predicting the Response to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer.

In Ja Park, Yun Suk Yu, Bilal Mustafa, Jin Young Park, Yong Bae Seo, Gun-Do Kim, Jinpyo Kim, Chang Min Kim, Hyun Deok Noh, Seung-Mo Hong and 6 more

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  17. Significance ofCancers · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

In Ja ParkDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0001-5355-3969
Yun Suk YuCbsBioscience Inc., Daejeon 34036, Korea.
Bilal MustafaDepartment of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon 21565, Korea.ORCID 0000-0003-0865-7974
Jin Young ParkCbsBioscience Inc., Daejeon 34036, Korea.
Yong Bae SeoCbsBioscience Inc., Daejeon 34036, Korea.
Gun-Do KimCbsBioscience Inc., Daejeon 34036, Korea.
Jinpyo KimCbsBioscience Inc., Daejeon 34036, Korea.ORCID 0000-0002-4370-1195
Chang Min KimCbsBioscience Inc., Daejeon 34036, Korea.
Hyun Deok NohCbsBioscience Inc., Daejeon 34036, Korea.
Seung-Mo HongDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Yeon Wook KimAsan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Mi-Ju KimAsan Institute for Life Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Adnan Ahmad AnsariDepartment of Industrial and Environmental Engineering, Graduate School of Environment, Gachon University, Incheon 21565, Korea.ORCID 0000-0002-6207-8351
Luigi BuonaguroCancer Immunoregulation Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, 80131 Naples, Italy.
Sung-Min AhnDepartment of Genome Medicine and Science, College of Medicine, Gachon University, Incheon 21565, Korea.
Chang-Sik YuDepartment of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0001-9401-9981

Funding

Korea Institute for Advancement of Technology N055700005Ministry of Trade, Industry and Energy 000000
6 · The paper itself

Abstract

Preoperative chemoradiotherapy (PCRT) and subsequent surgery is the standard multimodal treatment for locally advanced rectal cancer (LARC), albeit PCRT response varies among the individuals. This creates a dire necessity to identify a predictive model to forecast treatment response outcomes and identify patients who would benefit from PCRT. In this study, we performed a gene expression study using formalin-fixed paraffin-embedded (FFPE) tumor biopsy samples from 156 LARC patients (training cohort

Indexed as

biomarkerlocally advanced rectal cancerNanoString analysispreoperative chemoradiotherapy

Identifiers

PMID32225122
PMCPMC7226472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.