ArticleMicromachines2020
Bubbles Moving in Blood Flow in a Microchannel Network: The Effect on the Local Hematocrit.
Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Circulating Bubbles in Decompression Sickness: Pathophysiology and Experimental Models.Biomolecules · 2026Review
- Laser-Induced Graphene on Biocompatible PDMS/PEG Composites for Limb Motion Sensing.Sensors (Basel, Switzerland) · 2025Article
- Understanding the Impact of Synthetic Hematocrit Levels and Biomimetic Channel Widths on Bubble Parameters in Vascular Systems on a Chip.Biomimetics (Basel, Switzerland) · 2025Article
- Magnetic Microrobots as a Platform for Cell Clean Up.... International Conference on Manipulation Automation and Robotics at Small Scales (MARSS). International Conference on Manipulation Automation and Robotics at Small Scales · 2023Article
- Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction.Journal of the American Heart Association · 2023Article
- A review on non-Newtonian fluid models for multi-layered blood rheology in constricted arteries.Archive of applied mechanics = Ingenieur-Archiv · 2023Review
- Analysis of Polarization Images in the Microphysical Blood Parameters Research for the Hematocrit Diagnostics.Micromachines · 2022Article
- Emergence of debubblers in microfluidics: A critical review.Biomicrofluidics · 2022Review
- Properties and Applications of PDMS for Biomedical Engineering: A Review.Journal of functional biomaterials · 2021Review
- Review
- Manual and Automatic Image Analysis Segmentation Methods for Blood Flow Studies in Microchannels.Micromachines · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Air inside of blood vessels is a phenomenon known as gas embolism. During the past years, studies have been performed to assess the influence of air bubbles in microcirculation. In this study, we investigated the flow of bubbles in a microchannel network with several bifurcations, mimicking part of a capillary system. Thus, two working fluids were used, composed by sheep red blood cells (RBCs) suspended in a Dextran 40 solution with different hematocrits (5% and 10%). The experiments were carried out in a polydimethylsiloxane (PDMS) microchannel network fabricated by a soft lithography. A high-speed video microscopy system was used to obtain the results for a blood flow rate of 10 µL/min. This system enables the visualization of bubble formation and flow along the network. The results showed that the passage of air bubbles strongly influences the cell's local concentration, since a higher concentration of cells was observed upstream of the bubble, whereas a lower local hematocrit was visualized at the region downstream of the bubble. In bifurcations, bubbles may split asymmetrically, leading to an uneven distribution of RBCs between the outflow branches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.