ArticleNutrients2020
Glutamine Supplementation Prevents Chronic Stress-Induced Mild Cognitive Impairment.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Unraveling the Diet-Learning Nexus: a cross-sectional deep dive into Iranian adolescents' nutrient patterns and learning difficulties.BMC nutrition · 2026Article
- Comparative Analysis of Hypothalamic Responses to Stress and Glutamine Supplementation in Diet-Induced Obese Mice: A Study of Sex Differences.Inflammation · 2026Article
- DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs.Frontiers in psychiatry · 2026Article
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Cognitive dysfunction-an under looked avenue to promote health in incarcerated elderly population through yoga.Frontiers in human neuroscience · 2025Article
- Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors.Brain, behavior, and immunity · 2024Article
- The Role of Glutamine Homeostasis in Emotional and Cognitive Functions.International journal of molecular sciences · 2024Review
- Neuroprotective effect ofHeliyon · 2023Article
- Article
- Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress.International journal of molecular sciences · 2023Article
- Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.Frontiers in pharmacology · 2022Article
- Possible modulation of nervous tension-induced oxidative stress by vitamin E.Saudi journal of biological sciences · 2020Article
- The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We recently reported that glutamine (Gln) supplementation protected glutamatergic neurotransmission from the harmful effects of chronic stress. Altered glutamatergic neurotransmission is one of the main causes of cognitive disorders. However, the cognitive enhancer function of Gln has not been clearly demonstrated thus far. Here, we evaluated whether and how Gln supplementation actually affects chronic stress-induced cognitive impairment. Using a chronic immobilization stress (CIS) mouse model, we confirmed that chronic stress induced mild cognitive impairment (MCI) and neuronal damage in the hippocampus. In contrast, Gln-supplemented mice did not show evidence of MCI. To investigate possible underlying mechanisms, we confirmed that CIS increased plasma corticosterone levels as well as brain and plasma levels of reactive oxygen/nitrogen species. CIS also increased levels of inducible nitric oxide synthase and NADPH oxidase subunits (p47
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.