Evidence map›Paper›PMID 32224897›Full record

ArticleCancers2020

Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2.

Jiří Novotný, Veronika Bandúrová, Hynek Strnad, Martin Chovanec, Miluše Hradilová, Jana Šáchová, Martin Šteffl, Josipa Grušanović, Roman Kodet, Václav Pačes and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Development of a Clinical Assay to Guide Patient Therapy in HPV-Associated Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jiří NovotnýLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Veronika BandúrováInstitute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Hynek StrnadLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Martin ChovanecDepartment of Otorhinolaryngology, 3rd Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.
Miluše HradilováLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Jana ŠáchováLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Martin ŠtefflDepartment of Otorhinolaryngology, 3rd Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.
Josipa GrušanovićInstitute of Microbiology of the Czech Academy of Sciences, 142 00 Prague, Czech Republic.
Roman KodetDepartment of Pathology and Molecular Medicine, Charles University, 2nd Faculty of Medicine and Faculty Hospital Motol, 150 06 Prague, Czech Republic.
Václav PačesLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Lukáš LacinaInstitute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.ORCID 0000-0002-1750-9933
Karel SmetanaInstitute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.ORCID 0000-0002-7878-8403
Jan PlzákDepartment of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Charles University, Faculty Hospital Motol, 150 06 Prague, Czech Republic.ORCID 0000-0003-3710-4455
Michal KolářLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Tomáš VomastekInstitute of Microbiology of the Czech Academy of Sciences, 142 00 Prague, Czech Republic.
Charles University · CZCzech Academy of Sciences, Institute of Molecular Genetics · CZCzech Academy of Sciences · CZ

Funding

Agentura Pro Zdravotnický Výzkum České Republiky 16-29032AGrantová Agentura České Republiky 18-11908SMinisterstvo Školství, Mládeže a Tělovýchovy Operational Programme Research, Development and Education under the project "Center for Tumor Ecology - Research of the Cancer Microenvironment Supporting Cancer Growth and Spread" (reg. No. CZ.02.1.01/0.0/0.0/16_019/0000785)Ministerstvo Školství, Mládeže a Tělovýchovy Research and Development for Innovations Operational Program under project no. CZ.1.05/2.1.00/19.0400
6 · The paper itself

Abstract

Aberrant regulation of the cell cycle is a typical feature of all forms of cancer. In head and neck squamous cell carcinoma (HNSCC), it is often associated with the overexpression of cyclin D1 (

Indexed as

11q13 amplificationCCND1CCND2CCND3cell cycleD-type cyclinshead and neck squamous cell carcinomahuman papillomaviruspaired tumor-normal samplespatient survival

Identifiers

PMID32224897
PMCPMC7226528
OpenAlexW3013684546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.