Evidence map›Paper›PMID 32224769›Full record

ArticleCritical care medicine2020

Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).

Waleed Alhazzani, Morten Hylander Møller, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba and 26 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 462 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
462citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04353674 nacompletednot on this map

Novel Extracorporeal Treatment to Modulate Hyperinflammation in COVID-19 Patients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2020 to 2024Enrolled12ConditionsCOVID-19, SARSArmsControl group, SLEDD with a L-MOD
NCT04457817 terminatednot on this map

CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients With COVID-19

TypeobservationalSponsorUniversity of Colorado, DenverRan2020 to 2021Enrolled16ConditionsCOVIDArmsCRI
NCT04655638 nacompletednot on this mapstarted 2021, after this paper: background citation

High-Flow Nasal Therapy Versus Conventional Oxygen Therapy in Patients With COVID-19: A Randomized Controlled Trial (The COVID-HIGH Trial)

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoRan2021 to 2021Enrolled364ConditionsCovid19, Acute Respiratory FailureArmsHigh Flow Nasal Therapy, Conventional Oxygen Therapy
3 · Its place in the literature

Who cites it

462 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  10. Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.Journal of aerosol medicine and pulmonary drug delivery · 2021
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  14. Restrictive fluids versus standard care in adults with sepsis in the emergency department (REFACED): A multicenter, randomized feasibility trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022
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402 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Waleed AlhazzaniDepartment of Medicine, McMaster University, Hamilton, Canada.
Morten Hylander MøllerCopenhagen University Hospital Rigshospitalet, Department of Intensive Care, Copenhagen, Denmark.
Yaseen M ArabiIntensive Care Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.
Mark LoebDepartment of Medicine, McMaster University, Hamilton, Canada.
Michelle Ng GongDivision of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, New York, USA.
Eddy FanInterdepartmental Division of Critical Care Medicine and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Simon OczkowskiDepartment of Medicine, McMaster University, Hamilton, Canada.
Mitchell M LevyWarren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
Lennie DerdeDepartment of Intensive Care Medicine, University medical Center Utrecht, Utrecht University, the Netherlands.
Amy DzierbaDepartment of Pharmacy, New York-Presbyterian Hospital, Columbia University Irving Medical Center, New York, New York, USA.
Bin DuMedical ICU, Peking Union Medical College Hospital, Beijing.
Michael AboodiDivision of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, New York, USA.
Hannah WunschDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Maurizio CecconiDepartment of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Younsuck KohDepartment of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Daniel S ChertowCritical Care Medicine Department, National Institutes of Health Clinical Center and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, USA.
Kathryn MaitlandFaculty of Medicine, Imperial College, London, UK.
Fayez AlshamsiDepartment of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Emilie Belley-CoteDepartment of Medicine, McMaster University, Hamilton, Canada.
Massimiliano GrecoDepartment of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Matthew LaundyMicrobiology and Infection control, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.
Jill S MorganEmory University Hospital, Atlanta, Georgia, USA.
Jozef KeseciogluDepartment of Intensive Care Medicine, University medical Center Utrecht, Utrecht University, the Netherlands.
Allison McGeerDivision of Infectious Diseases, University of Toronto, Toronto, Canada.
Leonard MermelWarren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
Manoj J MammenDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Paul E AlexanderDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Canada.
Amy ArringtonHouston Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.
John E CentofantiDepartment of Anesthesia, McMaster University, Hamilton, Canada.
Giuseppe CiterioDepartment of Medicine and Surgery, Milano-Bicocca University, Milano, Italy.
Bandar BawDepartment of Medicine, McMaster University, Hamilton, Canada.
Ziad A MemishDirector, Research & Innovation Centre, King Saud Medical City, Ministry of Health, Riyadh, Kingdom of Saudi Arabia.
Naomi HammondCritical Care Division, The George Institute for Global Health and UNSW Sydney, Australia.
Frederick G HaydenDivision of Infectious Diseases and International Health, Department of Medicine, University of, Virginia, School of Medicine, Charlottesville, Virginia, USA.
Laura EvansDivision of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, USA.
Andrew RhodesAdult Critical Care, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

methodsWe formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

resultsThe Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which four are best practice statements, nine are strong recommendations, and 35 are weak recommendations. No recommendation was provided for six questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy.

conclusionThe Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19Critical IllnessDiagnostic Techniques and ProceduresHumansInfection ControlIntensive Care UnitsPandemicsPneumonia, ViralPractice Guidelines as TopicRespiration, ArtificialSARS-CoV-2Shock

Identifiers

PMID32224769
PMCPMC7176264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.