ArticleBone2020
Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators.
Open access · greenAbstract read
In one paragraph
Article in Bone, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Mineral-targeted alkaline phosphatase improves bone graft-mediated alveolar bone defect healing in mice.Journal of periodontology · 2026Article
- Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis.Physiological genomics · 2025Article
- Reduced orthodontic tooth movement inJBMR plus · 2025Article
- Cementum regeneration strategies: Insights from development and periodontal microenvironment.Frontiers in cell and developmental biology · 2025Review
- Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation.Calcified tissue international · 2024Article
- Dentoalveolar Alterations in an Adenine-Induced Chronic Kidney Disease Mouse Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.Cell death & disease · 2023Article
- Periodontal regeneration: Lessons from the periodontal ligament-cementum junction in diverse animal models.Frontiers in dental medicine · 2023Article
- Dual peptide-functionalized hydrogels differentially control periodontal cell function and promote tissue regeneration.Biomaterials advances · 2022Article
- Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-DJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice.Journal of dental research · 2021Article
- Ablation of Pyrophosphate Regulators Promotes Periodontal Regeneration.Journal of dental research · 2021Article
- Review
- Tissue-Nonspecific Alkaline Phosphatase-A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease.Biomolecules · 2020Review
- Insights into dental mineralization from three heritable mineralization disorders.Journal of structural biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 2 countries.
E Y ChuNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: Emily.chu@nih.gov.
T D VoNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
M B ChavezBiosciences Division, College of Dentistry, The Ohio State University, Columbus, OH, USA.
A NagasakiNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
E L MertzNational Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
F H NocitiDepartment of Prosthodontics & Periodontics, State University of Campinas, Piracicaba Dental School, Piracicaba, São Paulo, Brazil.
S F AitkenNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
D KavanaghDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
K ZimmermanDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
X LiDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
P R StabachDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
D T BraddockDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
J L MillánSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
B L FosterBiosciences Division, College of Dentistry, The Ohio State University, Columbus, OH, USA.
M J SomermanNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Yale University · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institutes of Health · USThe Ohio State University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USSanford Burnham Prebys Medical Discovery Institute · USUniversidade Estadual de Campinas (UNICAMP) · BR
Funding
MOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2MLaboratory of Oral Connective Tissue BiologyZIAAR041196 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI SOMERMAN, MARTHA · 2013 to 2021
$8.9MHigh-definition infrared micro-spectroscopic imaging of biomaterialsZIAHD008810 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEIKIN, SERGEY · 2009 to 2022
$2.5MFunctions of extracellular matrix proteins in dental and skeletal mineralizationR01DE027639 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2019 to 2026
$2.3MExtracellular Matrix and Phosphate/Pyrophosphate Metabolism in Cementum FormationR00AR066110 · NIAMS · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2015 to 2017
$747kRole of tissue-nonspecific alkaline phosphatase in dentoalveolar development and diseaseR03DE028411 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$312kFunction of cementocytes in cellular cementum formation and resorptionR03DE028632 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$307kIntramural NIH HHS ZIA AR041196NIAMS NIH HHS R00 AR066110NIDCR NIH HHS R01 DE012889NIDCR NIH HHS R01 DE027639NIDCR NIH HHS R03 DE028411NIDCR NIH HHS R03 DE028632
Abstract
Pyrophosphate (PP
Indexed as
CementogenesisDiphosphatesAnimalsDental CementumMiceOsteoclastsDiphosphatesBoneCementumMineralized tissue/developmentTooth development
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.