Evidence map›Paper›PMID 32224136›Full record

ArticleBiochemical pharmacology2020

Assessment of biased agonism at the A

Eline Pottie, Dilip K Tosh, Zhan-Guo Gao, Kenneth A Jacobson, Christophe P Stove

Open access · bronzeAbstract read
In one paragraph

Article in Biochemical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. 4'-Thionucleosides as adenosine AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  8. Article
  9. Assay-Dependent Inverse Agonism at the AACS pharmacology & translational science · 2023
    Article
  10. Article
  11. A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  12. Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HTJournal of medicinal chemistry · 2022
    Article
  13. Article
  14. Article
  15. The P2YInternational journal of molecular sciences · 2022
    Article
  16. Article
  17. Article
  18. AEuropean journal of medicinal chemistry · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Eline PottieLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD 20802, USA.
Zhan-Guo GaoLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD 20802, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD 20802, USA.
Christophe P StoveLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address: Christophe.Stove@UGent.be.
National Institutes of Health · USGhent University · BE

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Drugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854k
Intramural NIH HHS Z01 DK031117Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

The A

Indexed as

AdenosineAdenosine A3 Receptor Agonistsbeta-Arrestin 2Drug Evaluation, PreclinicalFlow CytometryGTP-Binding Protein alpha SubunitsHEK293 CellsHumansLigandsLuminescent MeasurementsReceptor, Adenosine A3Signal TransductionStructure-Activity RelationshipTransduction, GeneticTransfectionAdenosineAdenosine A3 Receptor AgonistsADORA3 protein, humanbeta-Arrestin 2GTP-Binding Protein alpha SubunitsLigandsReceptor, Adenosine A3A(3) adenosine receptorBiased signalingG protein-coupled receptorStructure-activity relationshipβ-Arrestin2

Identifiers

PMID32224136
PMCPMC7382964
OpenAlexW3013047209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.