Evidence map›Paper›PMID 32223923›Full record

ReviewBioorganic & medicinal chemistry letters2020

Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels.

Kimberly A Wodzanowski, Samantha E Cassel, Catherine L Grimes, April M Kloxin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kimberly A WodzanowskiChemistry and Biochemistry, University of Delaware, Newark, DE 19716, United States.
Samantha E CasselChemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States.
Catherine L GrimesChemistry and Biochemistry, University of Delaware, Newark, DE 19716, United States; Biological Sciences, University of Delaware, Newark, DE 19716, United States. Electronic address: cgrimes@udel.edu.
April M KloxinChemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States; Materials Science and Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: akloxin@udel.edu.
University of Delaware · US

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAININGT32GM008550 · NIGMS · UNIVERSITY OF DELAWARE · PI BAHNSON, BRIAN J · 1994 to 2018
$5.0M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Unraveling fibrosis with dynamic microenvironments and molecular toolsDP2HL152424 · NHLBI · UNIVERSITY OF DELAWARE · PI KLOXIN, APRIL M · 2019 to 2019
$2.4M
Metabolic carbohydrate cell wall probes for bacterial structure and immune recognition studiesU01CA221230 · NCI · UNIVERSITY OF DELAWARE · PI GRIMES, CATHERINE LEIMKUHLER · 2017 to 2019
$1.1M
NCI NIH HHS U01 CA221230NHLBI NIH HHS DP2 HL152424NIGMS NIH HHS T32 GM008550NIGMS NIH HHS T32 GM133395
6 · The paper itself

Abstract

Healthy function of the gut microenvironment is dependent on complex interactions between the bacteria of the microbiome, epithelial and immune (host) cells, and the surrounding tissue. Misregulation of these interactions is implicated in disease. A range of tools have been developed to study these interactions, from mechanistic studies to therapeutic evaluation. In this Digest, we highlight select tools at the cellular and molecular level for probing specific cell-microenvironment interactions. Approaches are overviewed for controlling and probing cell-cell interactions, from transwell and microfluidic devices to engineered bacterial peptidoglycan fragments, and cell-matrix interactions, from three-dimensional scaffolds to chemical handles for in situ modifications.

Indexed as

Host-Parasite InteractionsAnimalsBacteriaCellular MicroenvironmentExtracellular MatrixFluorescent DyesHumansImmunity, InnateIntestinesModels, BiologicalFluorescent DyesBacterial peptidoglycanBiomaterialsBioorthogonal chemistryCell-matrix interactionsCo-cultureGastrointestinalHost-bacteria interactionsSynthetic culture models

Identifiers

PMID32223923
PMCPMC7476074
OpenAlexW3011582676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.