ArticleeLife2020
Theoretical relation between axon initial segment geometry and excitability.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- The axon initial segment-associated microglia regulate neuronal activity and visual perception.Cell research · 2026Article
- A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.Nature communications · 2026Article
- Morphological details contribute to neuronal response variability within the same cell type.Frontiers in cellular neuroscience · 2026Article
- A neuron type-specific microexon inbioRxiv : the preprint server for biology · 2025Article
- Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds.PLoS biology · 2025Article
- Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Theory of axo-axonic inhibition.PLoS computational biology · 2025Article
- Ex Vivo Functional Characterization of Mouse Olfactory Bulb Projection Neurons Reveals a Heterogeneous Continuum.eNeuro · 2025Article
- Visual activity enhances neuronal excitability in thalamic relay neurons.Science advances · 2025Article
- Motor learning changes the axon initial segment of the spinal motoneuron.The Journal of physiology · 2024Article
- Intrinsic Plasticity Mechanisms of Repetitive Transcranial Magnetic Stimulation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- How neuronal morphology impacts the synchronisation state of neuronal networks.PLoS computational biology · 2024Article
- Concussive Head Trauma Deranges Axon Initial Segment Function in Axotomized and Intact Layer 5 Pyramidal Neurons.Journal of neurotrauma · 2024Article
- Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons.Cell reports · 2023Article
- Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment.International journal of molecular sciences · 2023Article
- Sodium channel endocytosis drives axon initial segment plasticity.Science advances · 2023Article
- Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex.Neuroscience bulletin · 2023Article
- Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity.Cellular and molecular life sciences : CMLS · 2023Article
- Comparative Effects of Domain-Specific Human Monoclonal Antibodies Against LGI1 on Neuronal Excitability.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy.Translational vision science & technology · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial segment (AIS). Both position and length of the AIS vary across and within neuron types, with activity, development and pathology. What is the impact of AIS geometry on excitability? Direct empirical assessment has proven difficult because of the many potential confounding factors. Here, we carried a principled theoretical analysis to answer this question. We provide a simple formula relating AIS geometry and sodium conductance density to the somatic voltage threshold. A distal shift of the AIS normally produces a (modest) increase in excitability, but we explain how this pattern can reverse if a hyperpolarizing current is present at the AIS, due to resistive coupling with the soma. This work provides a theoretical tool to assess the significance of structural AIS plasticity for electrical function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.