Evidence map›Paper›PMID 32223753›Full record

ArticleArthritis research & therapy2020

Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis.

Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee, Hye Young Kim

Abstract read
In one paragraph

Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seungwon RyuLaboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Eun Young LeeDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Dong Ki KimDivision of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Yon Su KimDivision of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Doo Hyun ChungDepartment of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
Ji Hyung KimCollege of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
Hajeong LeeDivision of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea. mdhjlee@gmail.com.
Hye Young KimLaboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea. hykim11@snu.ac.kr.ORCID 0000-0001-5978-512X

Funding

Korea Healthcare Technology R&D Project, Ministry of Health and Welfare HI15C3083Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Korea HI15C1736National Research Foundation of Korea SRC 2017R1A5A1014560
6 · The paper itself

Abstract

backgroundInnate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pathogenesis of lupus nephritis (LN).

methodsThe percentage of ILCs within the peripheral blood mononuclear cell (PBMC) population and urine of patients with LN (n = 16), healthy controls (HC; n = 8), and disease controls (ANCA-associated vasculitis (AAV; n = 6), IgA nephropathy (IgAN; n = 9), and other glomerular diseases (n = 5)) was determined by flow cytometry analysis. In addition, ILCs were sorted and cultured with plasma from LN patients or HC to elucidate whether the reduced population of CD117

resultsThe percentage of total ILCs and CD117

conclusionsThe percentage of CD117

Indexed as

AdultCell CountCell DifferentiationCells, CulturedCytokinesFlow CytometryHumansImmunity, InnateLeukocytes, MononuclearLupus NephritisLymphocytesMaleMiddle AgedProto-Oncogene Proteins c-kitStem CellsYoung AdultCytokinesProto-Oncogene Proteins c-kitAutoimmune kidney diseaseCytokineInnate lymphoid cells (ILCs)Lupus nephritis

Identifiers

PMID32223753
PMCPMC7104540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.