Evidence map›Paper›PMID 32223506›Full record

ArticleRNA biology2020

Modulation of mammalian translation by a ribosome-associated tRNA half.

Yulia Gonskikh, Matthias Gerstl, Martin Kos, Nicole Borth, Markus Schosserer, Johannes Grillari, Norbert Polacek

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Pyrrolysine supply and demand shapes the translational landscape inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Roles and regulation of tRNA-derived small RNAs in animals.Nature reviews. Molecular cell biology · 2024
    Review
  16. Review
  17. Article
  18. 3'-tRF-CysFunctional & integrative genomics · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Yulia GonskikhDepartment of Chemistry and Biochemistry, University of Bern , Bern, Switzerland.
Matthias GerstlDepartment of Biotechnology, BOKU - University of Natural Resources and Life Sciences , Vienna, Austria.ORCID 0000-0001-5331-5776
Martin KosBiochemistry Center, University of Heidelberg , Heidelberg, Germany.
Nicole BorthDepartment of Biotechnology, BOKU - University of Natural Resources and Life Sciences , Vienna, Austria.
Markus SchossererDepartment of Biotechnology, BOKU - University of Natural Resources and Life Sciences , Vienna, Austria.ORCID 0000-0003-2025-0739
Johannes GrillariDepartment of Biotechnology, BOKU - University of Natural Resources and Life Sciences , Vienna, Austria.
Norbert PolacekDepartment of Chemistry and Biochemistry, University of Bern , Bern, Switzerland.
BOKU University · ATUniversity of Bern · CHHeidelberg University · DELudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Originally considered futile degradation products, tRNA-derived RNA fragments (tdRs) have been shown over the recent past to be crucial players in orchestrating various cellular functions. Unlike other small non-coding RNA (ncRNA) classes, tdRs possess a multifaceted functional repertoire ranging from regulating transcription, apoptosis, RNA interference, ribosome biogenesis to controlling translation efficiency. A subset of the latter tdRs has been shown to directly target the ribosome, the central molecular machine of protein biosynthesis. Here we describe the function of the mammalian tRNA

Indexed as

Protein BiosynthesisAnimalsCell LineCHO CellsCricetulusHumansMolecular WeightRibosomesRNA, TransferRNA, UntranslatedRNA, TransferRNA, UntranslatedncRNArancRNAribosometranslation regulationtRNA-derived fragmentstRNA halves

Identifiers

PMID32223506
PMCPMC7549673
OpenAlexW3013572122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.