Evidence map›Paper›PMID 32223398›Full record

ArticleGut microbes2020

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota.

Vishal Singh, Beng San Yeoh, Ahmed A Abokor, Rachel M Golonka, Yuan Tian, Andrew D Patterson, Bina Joe, Mathias Heikenwalder, Matam Vijay-Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 61 citations in OpenAlex.

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  18. Synthesis and Characterization of FeInternational journal of biomaterials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Vishal SinghDepartment of Nutritional Sciences, The Pennsylvania State University , University Park, PA, USA.
Beng San YeohMicrobiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.ORCID 0000-0002-7723-8733
Ahmed A AbokorMicrobiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.
Rachel M GolonkaMicrobiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.
Yuan TianDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA, USA.ORCID 0000-0001-6174-3359
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, PA, USA.ORCID 0000-0003-2073-0070
Bina JoeMicrobiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.
Mathias HeikenwalderDivision of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ) , Heidelberg, Germany.
Matam Vijay-KumarMicrobiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.
University of Toledo · USPennsylvania State University · USGerman Cancer Research Center · DE

Funding

Genetic, Epigenetic and Dietary Salt effects on Microbiota and HypertensionR01HL143082 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI JOE, BINA · 2018 to 2021
$2.6M
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular CarcinomaR01CA219144 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI VIJAY-KUMAR, MATAM · 2017 to 2021
$1.6M
NCI NIH HHS R01 CA219144NHLBI NIH HHS R01 HL143082
6 · The paper itself

Abstract

Owing to their health benefits, dietary fermentable fibers, such as refined inulin, are increasingly fortified in processed foods to enhance their nutritional value. However, we previously demonstrated that when inulin was fed to Toll-like receptor 5 deficient (T5KO) mice susceptible to dysbiosis, a subset of them developed cholestasis and subsequently liver cancer in a gut microbiota-dependent manner. Therefore, we hypothesized that clearance of bacterial taxa, and thereby gut metabolites, involved in the onset and progression to liver cancer could abate the disease in these mice. Such a reshaping of microbiota by vancomycin treatment was sufficient to halt the development of liver cancer in inulin-fed T5KO mice; however, this intervention did not remedy disease penetrance for cholestatic liver injury and its sequelae, including hyperbilirubinemia, hypolipidemia, cholemia and liver fibrosis. Selective depletion of gut bacterial communities was observed in vancomycin-treated mice, including Gram-positive

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBile Acids and SaltsDietary FiberDietary SupplementsDysbiosisFatty Acids, VolatileFermentationInulinLiver NeoplasmsMiceMice, KnockoutToll-Like Receptor 5VancomycinBile Acids and SaltsDietary FiberFatty Acids, VolatileInulinTlr5 protein, mouseToll-Like Receptor 5Vancomycinbile acidsbilirubincholemiacholestasisfermentationhepatocellular carcinomainulinsoluble fiberToll-like receptor 5

Identifiers

PMID32223398
PMCPMC7524287
OpenAlexW3013262440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.