Evidence map›Paper›PMID 32223377›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension.

Roy Freeman, Ben M W Illigens, Razvan Lapusca, Marta Campagnolo, Ahmad R Abuzinadah, Istvan Bonyhay, Dong-In Sinn, Mitchell Miglis, Jeffrey White, Christopher H Gibbons

2 registry-linked trialsAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05400174 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2021 to 2027Enrolled60ConditionsParkinson Disease, Orthostatic Hypotension, DysautonomiaArmsTilt table (upright position)
NCT06252376 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in Parkinson's Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2029Enrolled0ConditionsParkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive ImpairmentArmsHead-up tilt table
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Orthostatic hypotension and acute cognitive dysfunction in Parkinson's disease: insights from functional near-infrared spectroscopy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  6. Beyond blood pressure fall: a mechanistic framework for symptom generation in orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  7. Article
  8. Orthostatic hypotension and complaints: not a clear-cut relation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  9. Article
  10. Symptoms are an optimal target for orthostatic hypotension screening and management: an argument in favor.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Review
  11. Article
  12. Autonomic debate: symptoms are an optimal target for orthostatic hypotension screening and management. An argument in opposition.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roy FreemanFrom the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.F., B.M.W.I., I.B., C.H.G.).
Ben M W IlligensFrom the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.F., B.M.W.I., I.B., C.H.G.).
Razvan LapuscaDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Germany (R.L.).
Marta CampagnoloDepartment of Neurosciences, University of Padova, Italy (M.C.).
Ahmad R AbuzinadahDepartment of Internal Medicine, King Abdulaziz University Hospital, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia (A.R.A.).
Istvan BonyhayFrom the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.F., B.M.W.I., I.B., C.H.G.).
Dong-In SinnDepartment of Neurology, Stanford Medical Center, Palo Alto, CA (D.-I.S., M.M.).
Mitchell MiglisDepartment of Neurology, Stanford Medical Center, Palo Alto, CA (D.-I.S., M.M.).
Jeffrey WhiteUniversity of Virginia School of Medicine, Charlottesville (J.W.).
Christopher H GibbonsFrom the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.F., B.M.W.I., I.B., C.H.G.).

Funding

Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, ROY · 2009 to 2018
$11.6M
NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

Failure to recognize symptoms of orthostatic hypotension (OH) may result in falls, syncope, and injuries. The relationship between orthostatic changes in blood pressure and symptom occurrence and severity is not known. The goal of the present study was to define the relationship between the occurrence and severity of the symptoms of orthostatic hypotension (OH) and (1) the upright systolic blood pressure (SBP) and (2) the fall in SBP after tilting in patients with OH. We prospectively studied 89 patients with OH. Reported BP values include the lowest BP in the first 3 minutes of tilt and the change in blood pressure during tilt. Subjects were queried about symptoms of orthostatic intolerance while supine and during the first 3 minutes of tilt testing using Question 1 of the Orthostatic Hypotension Questionnaire. Mean tilted SBP was 101.6±26.1 mm Hg and mean SBP fall 47.9±18.1 mm Hg. Mean symptom scores when upright were: light-headedness (2.3/10±2.7), dizziness (1.6/10±2.5), and impending blackout (0.8/10±1.9). The majority of patients were asymptomatic or mildly symptomatic and no discrete cutoff for symptoms was observed. The magnitude of the SBP fall (

Indexed as

Diagnostic Self EvaluationAgedAged, 80 and overAntihypertensive AgentsAsymptomatic DiseasesDizzinessFemaleHeart RateHumansHypertensionHypotension, OrthostaticMaleMiddle AgedNervous System DiseasesProspective StudiesSurveys and QuestionnairesAntihypertensive Agentsblood pressuredizzinesshypertension, supinehypotension, orthostaticsynucleinopathies

Identifiers

PMID32223377
PMCPMC12818701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.