ArticleHypertension (Dallas, Tex. : 1979)2020
Cumulative Blood Pressure Exposure, Basal Ganglia, and Thalamic Morphology in Midlife.
Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Cumulative blood pressure and risk of dementia and cognitive decline: a systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Higher APOB is associated with poor renal outcome in lupus nephritis.Clinical rheumatology · 2026Article
- Duration-related regional patterns of gray matter alterations in hypertension and their cognitive implications.Brain imaging and behavior · 2026Article
- Association between cumulative average BMI and cognitive decline: a 24-year cohort study.Journal of neurology · 2026Article
- When Alzheimer's pathology meets cardiometabolic risk: intrinsic subcortical-cortical connectivity signatures of retroactive interference in aging.Alzheimer's research & therapy · 2026Article
- Association of blood pressure variability with white matter hyperintensities and nigrostriatal dopaminergic deficits in drug-naïve Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population.Annals of medicine · 2025Article
- Association between cumulative blood pressure and the risk of cognitive impairment in Chinese older adults: a longitudinal study over 16 years.BMC geriatrics · 2025Article
- Cumulative Hepatitis B Surface Antigen/Hepatitis B Virus DNA Ratio in Immune-tolerant Hepatitis B Patients: A 10-year Follow-up Study.Journal of clinical and translational hepatology · 2025Article
- Cumulative remnant cholesterol and major adverse cardiovascular events among adults with type 2 diabetes.American journal of preventive cardiology · 2025Article
- Age-Specific Association Between Cumulative Blood Pressure Exposure and Atrial Fibrillation Risk in Adults.Journal of the American Heart Association · 2025Article
- Beyond volume: Unraveling the genetics of human brain geometry.Science advances · 2025Article
- Long-term cumulative physical activity associated with less cognitive decline: Evidence from a 16-year cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Association of Cumulative Exposure to Metabolic Score for Visceral Fat With the Risk of Cardiovascular Disease and All-Cause Mortality: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cumulative blood pressure load and cognitive decline in older adults: An observational analysis of two large cohorts.Cerebral circulation - cognition and behavior · 2025Article
- 7-Tesla magnetic resonance imaging for monitoring microstructural changes in the lenticulostriate artery-neural complex in patients with hypertension.Quantitative imaging in medicine and surgery · 2024Article
- Effects and Thresholds of Young to Midlife Vascular Risks on Brain Health.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study.Alzheimer's research & therapy · 2024Article
- Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
High blood pressure (BP) negatively affects brain structure and function. Hypertension is associated with white matter hyperintensities, cognitive and mobility impairment in late-life. However, the impact of BP exposure from young adulthood on brain structure and function in mid-life is unclear. Identifying early brain structural changes associated with BP exposure, before clinical onset of cognitive dysfunction and mobility impairment, is essential for understanding mechanisms and developing interventions. We examined the effect of cumulative BP exposure from young adulthood on brain structure in a substudy of 144 (61 female) individuals from the CARDIA (Coronary Artery Risk Development in Young Adults) study. At year 30 (Y
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.