ArticleAmerican journal of physiology. Renal physiology2020
Effects of uric acid dysregulation on the kidney.
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Design, Synthesis, and Biological Evaluation of Triazole-Linked Lignan-Monoterpenoid-Based Hybrid Molecules as Xanthine Oxidase Inhibitors with Potent In Vivo Efficacy.ACS medicinal chemistry letters · 2025Article
- Neutrophils and NETs in kidney disease.Nature reviews. Nephrology · 2025Review
- Drug-Induced Hypouricemia.Drug safety · 2025Review
- U-shaped relationship between uric acid levels and all-cause mortality in patients with hypertension.Scientific reports · 2025Article
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- Article
- Clinical significance of hypouricemia in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2023Article
- The correlation between serum uric acid and diabetic kidney disease in type 1 diabetes patients in Anhui, China.BMC nephrology · 2023Article
- Redox regulation in diabetic kidney disease.American journal of physiology. Renal physiology · 2023Review
- Metabolic reprogramming heterogeneity in chronic kidney disease.FEBS open bio · 2023Review
- Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency.Basic & clinical pharmacology & toxicology · 2023Article
- The dysfunction in intestinal microorganisms and enzyme activity as significant contributors to diarrhea with kidney-yang deficiency syndrome.Frontiers in microbiology · 2023Article
- The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors.Oxidative medicine and cellular longevity · 2021Review
- Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction.International journal of molecular sciences · 2020Review
- The Dual Role of Uric Acid: Pathological Implications Across Chronic Diseases and Current Approaches to Hyperuricemia Management.Discoveries (Craiova, Romania)Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recently, research has redirected its interests in uric acid (UA) from gout, an inflammatory disease in joints, to groups of closely interrelated pathologies associated with cardiovascular and kidney dysfunction. Many epidemiological, clinical, and experimental studies have shown that UA may play a role in the pathophysiology of the cardiorenal syndrome continuum; however, it is still unclear if it is a risk factor or a causal role. Hyperuricemia has been well studied in the past two decades, revealing mechanistic insights into UA homeostasis. Likewise, some epidemiological and experimental evidence suggests that hypouricemia can lead to cardiorenal pathologies. The goal of this review is to highlight why studying both hyperuricemia and hypouricemia is warranted as well as to summarize the relevance of UA to kidney function.
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