Evidence map›Paper›PMID 32223160›Full record

ArticleThe Journal of organic chemistry2020

Photo-Click-Facilitated Screening Platform for the Development of Hetero-Bivalent Agents with High Potency.

Lingyi Sun, Yongkang Gai, Christopher D McNitt, Jun Sun, Xiaohui Zhang, Wei Xing, Zhonghan Li, Vladimir V Popik, Dexing Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Light-Triggered Click Chemistry.Chemical reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lingyi SunDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0003-2111-8764
Yongkang GaiDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0001-6766-5240
Christopher D McNittDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Jun SunDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Xiaohui ZhangDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Wei XingDepartment of Radiology, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, China.
Zhonghan LiDepartment of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon 97239, United States.
Vladimir V PopikDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-9112-3935
Dexing ZengDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0003-4948-5275

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Novel Platform to achieve high avidity of heterodimers for targeted cancer imagingR21EB020737 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZENG, DEXING · 2015 to 2016
$424k
Solid-Phase Platform for the Preparation of Dual-receptor Targeted PET AgentsR21EB017317 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZENG, DEXING · 2013 to 2014
$415k
NCI NIH HHS P30 CA047904NIBIB NIH HHS R21 EB017317NIBIB NIH HHS R21 EB020737
6 · The paper itself

Abstract

A novel photo-click-based platform has been developed for rapid screening and affinity optimization of heterobivalent agents. This method allows for the efficient selection of high-affinity dual receptor-targeting agents

Indexed as

Receptors, Urokinase Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorClick ChemistryReproducibility of ResultsReceptors, Urokinase Plasminogen ActivatorUrokinase-Type Plasminogen Activator

Identifiers

PMID32223160
PMCPMC7483003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.