Evidence map›Paper›PMID 32223048›Full record

ReviewMolecular oncology2020

Particle therapy in Europe.

Cai Grau, Marco Durante, Dietmar Georg, Johannes A Langendijk, Damien C Weber

Registry-linked trialAbstract readReview
In one paragraph

Review in Molecular oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05203250 (CNAO REgistry triAL - REGAL), which is not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05203250 recruitingnot on this mapstarted 2021, after this paper: background citation

CNAO REgistry triAL - REGAL

Typeobservational_patient_registrySponsorCNAO National Center of Oncological HadrontherapyRan2021 to 2071Enrolled3,000ConditionsCancer, Oncology, Radiation Exposure, Radiotherapy Side EffectArmsHeavy-ion therapy (hadrontherapy)
3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Proton therapy in Spain: SEOR-SPROMP multidisciplinary recommendations developed through a RAND/UCLA consensus process.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
  3. Review
  4. Trade-offs in proton and photon radiotherapy for pituitary adenomas.Physics and imaging in radiation oncology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Cancer Pain: Radiotherapy as a Double-Edged Sword.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cai GrauDepartment of Oncology and Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3548-3527
Marco DuranteBiophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
Dietmar GeorgDepartment of Radiation Oncology, Medical University of Vienna/AKH Wien, Vienna, Austria.
Johannes A LangendijkDepartment of Radiation Oncology, University Medical Centrum Groningen, Groningen, The Netherlands.
Damien C WeberPaul Scherrer Institute, Villigen, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particle therapy using protons or heavier ions is currently the most advanced form of radiotherapy and offers new opportunities for improving cancer care and research. Ions deposit the dose with a sharp maximum - the Bragg peak - and normal tissue receives a much lower dose than what is delivered by X-ray therapy. Particle therapy has also biological advantages due to the high linear energy transfer of the charged particles around the Bragg peak. The introduction of particle therapy has been slow in Europe, but within the last decade, more than 20 clinical facilities have opened and facilitated access to this frontline therapy. In this review article, the basic concepts of particle therapy are reviewed along with a presentation of the current clinical indications, the European clinical research, and the established networks.

Indexed as

Heavy Ion RadiotherapyProton TherapyCooperative BehaviorDatabases as TopicEuropeHumansRandomized Controlled Trials as Topiccancerion beam therapyparticle therapyproton therapyradiationradiotherapy

Identifiers

PMID32223048
PMCPMC7332216

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.