ArticleEuropean journal of immunology2020
Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype.
Article in European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans.Cell reports · 2021Trial
- Life Course Malaria Exposure and SARS-CoV-2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort.Tropical medicine & international health : TM & IH · 2026Article
- SARS-CoV-2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults.European journal of immunology · 2026Article
- Vaccine-induced responses to R21/Matrix-M - an analysis of samples from a phase 1b age de-escalation, dose-escalation trial.Frontiers in immunology · 2025Article
- Atypical memory B cells from natural malaria infection produced broadly neutralizing antibodies against Plasmodium vivax variants.PLoS pathogens · 2025Article
- Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.Nature communications · 2023Article
- Single-cell profiling of CD11c+ B cells in atherosclerosis.Frontiers in immunology · 2023Article
- Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support.Science immunology · 2022Article
- Memory B cell diversity: insights for optimized vaccine design.Trends in immunology · 2022Review
- The development and function of CD11cFrontiers in immunology · 2022Review
- Alternative B Cell Differentiation During Infection and Inflammation.Frontiers in immunology · 2022Review
- Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria.Malaria journal · 2021Article
- Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes.Cell reports · 2021Article
- Properties and Roles of γδT Cells inFrontiers in cellular and infection microbiology · 2021Article
- Potential functions of atypical memory B cells in Plasmodium-exposed individuals.International journal for parasitology · 2020Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or non-Ag-specific mechanisms. We identified Plasmodium and bystander tetanus toxoid (TT) specific B cells in individuals from areas of previous and persistent exposure to malaria using tetramers. Malaria-specific B cells were more likely to be aMBCs than TT-specific B cells. However, TT-specific B cells from individuals with continuous exposure to malaria were more likely to be aMBCs than TT-specific B cells in individuals from areas where transmission has ceased. Finally, sequences of BCRs specific for a blood stage malaria-Ag were more highly mutated than sequences from TT-specific BCRs and under strong negative selection, indicative of ongoing antigenic pressure. Our data suggest both persistent Ag exposure and the inflammatory environment shape the B-cell response to malaria and bystander Ags.
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