ArticleDigestive diseases and sciences2021
Low Bone Mineral Density in Young Patients Newly Diagnosed with Inflammatory Bowel Disease.
Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- An explainable predictive machine learning model of osteopenia for perimenopausal women based on clinical data: a retrospective single-center study.Frontiers in endocrinology · 2026Article
- A multilayered genetic structure analysis between inflammatory bowel disease and bone density/osteoporosis.PloS one · 2025Article
- Genetic variants of MTHFR gene in relation to folic acid levels and bone mineral density in Polish patients with inflammatory bowel disease.Journal of applied genetics · 2024Article
- Risk Factors of Low Bone Mineral Density in Newly Diagnosed Pediatric Inflammatory Bowel Disease.Nutrients · 2023Article
- The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization.Frontiers in immunology · 2023Article
- Causal effects from inflammatory bowel disease on liver function and disease: a two-sample Mendelian randomization study.Frontiers in medicine · 2023Article
- Risk Factors for Worsening of Bone Loss in Patients Newly Diagnosed with Inflammatory Bowel Disease.Gastroenterology research and practice · 2022Article
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12 authors.
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Abstract
backgroundThe prevalence and risk factors of low bone mineral density (BMD) in Asian patients newly diagnosed with inflammatory bowel disease (IBD) have not been fully suggested.
aimsWe aimed to examine the prevalence and risk factors of low BMD in young Korean patients newly diagnosed with IBD.
methodsWe prospectively enrolled 132 patients aged less than 50 years and newly diagnosed with IBD from six tertiary referral centers in Korea between November 2014 and April 2017. BMD was measured by dual-energy X-ray absorptiometry, and then the Z-score was determined. We defined low BMD as a Z-score ≤ - 1.0.
resultsOf 68 patients with ulcerative colitis (UC), 22 (32.4%) had low BMD. Also, of 64 patients with Crohn's disease (CD), 24 (37.5%) showed low BMD. Results from multivariate regression analysis identified the risk factors for low BMD as a high level of alkaline phosphatase (ALP) (≥ 140 U/L) (P = 0.010) in UC patients, and being underweight (body mass index ≤ 18.5 kg/m
conclusionsOur study showed that about one-third of newly diagnosed IBD Asian patients had low BMD. The clinical factors associated with low BMD were a high level of ALP in UC patients, and being underweight, in CD patients. Therefore, measurements of BMD in young patients should be considered at the diagnosis of IBD.
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