ReviewCurrent osteoporosis reports2020
Effects of PTH and PTH Hypersecretion on Bone: a Clinical Perspective.
Review in Current osteoporosis reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Brown tumors in nuclear medicine: a systematic review.Annals of nuclear medicine · 2023Pooled it
- Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture.Obesity (Silver Spring, Md.) · 2026Trial
- Construction and validation of a predictive model for hypocalcemia after parathyroidectomy in patients with secondary hyperparathyroidism.Frontiers in endocrinology · 2022Trial
- Article
- Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss.Journal of cellular and molecular medicine · 2026Review
- Evaluation of Trabecular Bone Score and Bone Mineral Density in Patients with Primary Hyperparathyroidism under 50 Years Old.Journal of bone metabolism · 2026Article
- Trends in Clinical Features of Primary Hyperparathyroidism During 2013-2024.International journal of endocrinology · 2026Article
- Optimizing type H vessels formationBioactive materials · 2025Article
- Weekly Teriparatide Treatment Decreases Microdamage in Tibial Trabecular Bone of Ovariectomized Cynomolgus Monkeys.Cureus · 2025Article
- Exploring the threshold relationship between PTH level and P1NP level in patients with osteoporotic fractures: a retrospective cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Clinical evaluation of therapeutic efficacy of Teriparatide in osteoporotic patients with vertebral degeneration.Journal of orthopaedics · 2025Article
- Parathyroidectomy Positively Modulates Systemic Inflammation and Nutritional Status: Immune-Inflammation Index and Prognostic Nutritional Index in Primary Hyperparathyroidism.Medicina (Kaunas, Lithuania) · 2025Article
- Hip Fractures: Clinical, Biomaterial and Biomechanical Insights into a Common Health Challenge.Bioengineering (Basel, Switzerland) · 2025Review
- Wubi Shanyao pills ameliorate diet-induced postmenopausal osteoporosis in mice by enhancing calcium absorption.Frontiers in pharmacology · 2025Article
- Displaced patellar stress fracture revealing primary hyperparathyroidism: a case report.AME case reports · 2025Article
- Sex differences in the relationship between parathyroid hormone and uric acid in osteoporotic fracture patients: insights from a retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
- Wild bonobos experience unusually low bone resorption during early lactation relative to humans and other mammals.Evolutionary human sciences · 2025Article
- HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Article
- Fracture Risk in Patients on Hemodialysis: the Lower the Parathyroid Hormone the Better?Kidney international reports · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewHyperparathyroidism may be due to an autonomous hypersecretion of parathyroid hormone (PTH) or occurs in response to a number of physiological stimuli. A number of recent findings have provided new insights into the importance of the calcium-parathyroid-vitamin D axis to bone in normal physiology and pathological conditions. RECENT
findingsPTH is known to affect bone microarchitecture with different effects on cortical and trabecular bone compartments. In trabecular bone, PTH may exert anabolic effects, whereas PTH promotes bone resorption in cortical bone. Vertebral fractures are prevalent in primary hyperparathyroidism (PHPT), and patients seem to fracture at higher values of bone mineral density (BMD) than patients with osteoporosis. This may be explained by changes in bone microarchitecture, which cannot be detected by measuring BMD. Even in mild PHPT, bone seems to benefit from parathyroidectomy. In secondary hyperparathyroidism, bone seems much more susceptible to fracture with insufficient levels of vitamin D compared with a replete vitamin status. If elevated PTH levels cannot be explained by conditions known to cause secondary hyperparathyroidism, the condition is termed normocalcemic PHPT, which also has been associated with an increased risk of fractures. Hyperparathyroidism is harmful to bone, which is why it is of importance to normalize PTH levels either by parathyroidectomy in PHPT or by counteracting conditions known to increase PTH in secondary hyperparathyroidism.
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