ArticleMetabolomics : Official journal of the Metabolomic Society2020
Urine metabolomic analysis for monitoring internal load in professional football players.
Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Effects of high-intensity interval training on biomarkers and inflammatory factors in patients with heart failure: a meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2025Pooled it
- Metabolomics analyses and physical interventions in soccer: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2024Pooled it
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Urinary metabolomic signatures of muscle injury and recovery in elite football players.Metabolomics : Official journal of the Metabolomic Society · 2026Observational
- NMR-based metabolomics profile during a soccer season of a sub-elite soccer team.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Association Between Habitual Food Intake and Energy Metabolism-Related Urine Metabolites in Female Soccer Players.Molecular nutrition & food research · 2026Article
- Metabolomic Profiling Reveals Distinct Pathways in Degenerated and Non-degenerated Rotator Cuff Tears: Implications for Pathogenesis and Treatment.Current molecular medicine · 2026Article
- Energy production pathways of female soccer players during championships: a metabolomics approach.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- NMR-Based Metabolomics Reveals Position-Specific Signatures Associated with Physical Demands in Professional Soccer Players.Biomedicines · 2025Article
- Early changes in urineMetabolomics : Official journal of the Metabolomic Society · 2025Article
- The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research.Metabolites · 2025Article
- Sample Preparation for Metabolomic Analysis in Exercise Physiology.Biomolecules · 2024Review
- The expression of glycolysis-related proteins in urine significantly increases after running.Frontiers in physiology · 2024Article
- Unraveling athletic performance: Transcriptomics and external load monitoring in handball competition.PloS one · 2024Article
- Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments.Sports (Basel, Switzerland) · 2023Article
- Comparison of the effects of pea protein and whey protein on the metabolic profile of soccer athletes: a randomized, double-blind, crossover trial.Frontiers in nutrition · 2023Article
- Biomarkers of post-match recovery in semi-professional and professional football (soccer).Frontiers in physiology · 2023Review
- Article
- Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives.Proteomes · 2022Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe design of training programs for football players is not straightforward due to intra- and inter-individual variability that leads to different physiological responses under similar training loads.
objectiveTo study the association between the external load, defined by variables obtained using electronic performance tracking systems (EPTS), and the urinary metabolome as a surrogate of the metabolic adaptation to training.
methodsUrine metabolic and EPTS data from 80 professional football players collected in an observational longitudinal study were analyzed by ultra-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry and assessed by partial least squares (PLS) regression.
resultsPLS models identified steroid hormone metabolites, hypoxanthine metabolites, acetylated amino acids, intermediates in phenylalanine metabolism, tyrosine, tryptophan metabolites, and riboflavin among the most relevant variables associated with external load. Metabolic network analysis identified enriched pathways including steroid hormone biosynthesis and metabolism of tyrosine and tryptophan. The ratio of players showing a deviation from the PLS model of adaptation to exercise was higher among those who suffered a muscular lesion compared to those who did not.
conclusionsThere was a significant association between the external load and the urinary metabolic profile, with alteration of biochemical pathways associated with long-term adaptation to training. Future studies should focus on the validation of these findings and the development of metabolic models to identify professional football players at risk of developing muscular injuries.
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